与正常胃组织和GES-1细胞相比,胃癌组织和BGC-823细胞中miR-101-3p下调,STC-1 mRNA上调,且miR-101-3p水平与STC-1水平负相关,miR-101-3p水平与肿瘤分化程度、TNM分期、淋巴结转移显著相关(P< 0.05);过表达miR-101-3p可抑制STC-...
3p对STC-1的靶向调控关系;划痕实验,Transwell小室实验,Matrigel体外成管实验及Westernblot检测验证miR-101-3p靶向STC-1基因对癌细胞的侵袭转移和血管生成的影响及可能的机制,并通过裸鼠致瘤实验检测移植瘤的发展.结果胃癌组织中STC-1的表达水平高于正常组织.与正常胃组织和GES-1细胞相比,胃癌组织和BGC-823细胞中miR-...
Conclusions:Taken together, our results demonstrated a regulatory mechanism of miR-101-3p via STC1 in goat granulosa cells, and offered the first in vivo example of miR-101-3p and STC1 functions required for ovarian development.Xiaopeng AnHaidong MaYuhan LiuFu LiYuxuan SongGuang LiYueyu BaiBin...
MiR-101-3p also affected the key protein PI3K, PTEN, AKT and mTOR in PI3K-AKT pathway by STC1 , thereby suppressing proliferation and promoting apoptosis of granulosa cells. In vivo , the distribution and expression levels of miR-101-3p in mouse ovaries were determined through fluorescence in...
Long Noncoding RNA MALAT1 Promotes the Development of Colon Cancer by Regulating miR-101-3p/STC1 Axis [Retraction]LINCRNACOLON cancerCARCINOGENESISThe image for Figure 3A, HCT116, 0h, LV-MALAT1, has been duplicated with the image for Figure 3A, HT116, 48 h, LV-NC and...