在地塞米松诱导的C2C12肌管中检测miR-322的表达水平,结果显示地塞米松增加了miR-322的表达量(p0.05),这与以前的miRNA微阵列检测结果相似.为了研究miR-322的作用,人工合成的miR-322模拟物和miR-322抑制剂被使用去升高或降低C2C12肌管中miR-322的表达量(p0.05).免疫荧光和荧光定量PCR实验结果显示,过表达miR-322减小...
目的:前期研究发现肝纤维化中miR322表达升高,扶正化瘀方(FZHY)干预后miR322表达下降,本研究旨在验证miR322在实验性肝纤维化中的表达特点,细胞来源与功能作用.方法:采用CCl4,DMN,BDL三种肝纤维化模型,以Real-time PCR法验证miR322在肝纤维化模型中的表达.分别复制肝星状细胞活化模型,肝细胞损伤模型,肝窦内皮细胞损伤...
There is growing evidence that microRNAs play important roles in cellular responses to hypoxia and in pulmonary hypertensive vascular remodeling, but the exact molecular mechanisms involved are not fully elucidated. In this study, we identified miR-322 a
进一步成功制备了用于抑制miR-322和miR-29c表达的慢病毒载体，利用睾丸显微注射在小鼠睾丸中下调miR-322的表达，发现可引起小鼠精子DNA损伤，证实与睾丸中γH2AX的表达增加相关。通过生物信息学预测并实验鉴定出了候选miRNA的两个靶基因chk1和Ddx3x，精原细胞系中实验发现miR-322可抑制chk1的表达，抑制miR-322的表达...
Immune checkpoint blockade of the inhibitory immune receptors PD-L1, PD-1 and CTLA-4 has emerged as a successful treatment strategy for several advanced cancers. Here we demonstrate that miR-424(322) regulates the PD-L1/PD-1 and CD80/CTLA-4 pathways in c
miRNAs identified in this study, especially miR-322/-503, are potent regulators of early cardiac fate. 展开 关键词: microRNA, miR-322, miR-424, miR-503, cardiomyocyte DOI: 10.1073/pnas.1608256113 被引量: 14 年份: 2016 收藏 引用 批量引用 报错 分享 ...
The miR-322 mimic or TRAF3 knockdown blocked high glucose-increased TRAF3 protein expression and apoptosis, whereas the miR-322 inhibitor mimicked the effect of high glucose leading to TRAF3 up-regulation and apoptosis. This study demonstrates that both maternal diabetes and high glucose negatively...
传奇4国际服MIR4 75级主线任务 天道峰上层(二)半兽人王 视频播放量 95、弹幕量 0、点赞数 0、投硬币枚数 0、收藏人数 0、转发人数 0, 视频作者 我不扬波, 作者简介 你好。,相关视频:传奇MIR4 稀有材料 开蓝箱子攻略,传奇4国际服MIR4 7W战力过75级主线任务 道观连续剧情
【娱乐2v2】S3赛季:mir毁伤天赋+Rivah贼牧~1.19日直播 2319 8 46:57 App 【WLK 竞技场】毁伤贼牧Mir + Gekku~8.2日直播 5032 -- 2:35:26 App 【Mir】【WLK盗贼】毁伤PVP测试 8820 8 29:54 App #搬运#【Mir Chanimal】-双视角-S3贼术-TBC竞技场 2174 -- 2:12:37 App S3赛季:mir+uzb毁伤...