As one of the major neurotransmitters, norepinephrine (NE) is considered an effective regulator of ovarian functions like granulosa cell (GC) apoptosis. However, the mechanism between NE and GC apoptosis in rat is still unclear. In our study, GCs were isolated and cultured invitro with NE ...
Herein, a series of in vitro and in vivo experiments demonstrated that (1) ATF3 expression was significantly reduced in GC tissues and is associated with the survival of GCs; (2) the expression level of ATF3 affected GC cell proliferation and metastasis; (3) ATF3 was involved in Wnt/β-...
TRPM3 channel activity in vivo has been implicated in a variety of neuronal and non-neuronal cellular processes. These include secretion of insulin by pancreatic β cells
57% amino acid identity), TRPM3 (melastatin-2) is not directly associated with melanocyte differentiation or melanoma [30]. Rather, TRPM3 channel activity in vivo has been implicated in a variety of neuronal and non-neuronal cellular processes. These include secretion of insulin by pancreatic β...
MiR-27a was a differentially expressed miRNA in the pre-ovulatory follicles from Large White and Chinese Taihu sows27. The relative expression of mus musculus (mmu) miR-27a (0.57 ± 0.18, P = 0.016) was significantly lower in the GCs of follicles containing MII oocytes compared ...
Brain-derived neurotrophic factor (BDNF) was shown to induce expression of the miR-212/132 cluster in cortical neurons and retinal ganglion cells (RGCs),12, 27, 29 leading to the assumption that these miRNAs are involved in mediation of some BDNF effects, because they were known to play a...
Conclusion: The overexpression of miR-34a inhibits the activity of NGF and PRL, promotes apoptosis, and inhibits the proliferation and invasion of tumor cells.Guan, YuhuaChina Three Gorges UnivGuo, MinminYiling HospJiang, LaiXia, KailaiTang, HuaZheng, GangChen, Shaojuninternational journal of ...
(d) High protein level of TEAD1 and TEAD4 was detected in most of the GC cell lines (upper panel). And the corresponding quantification by densitometry was shown at nether panel. (e) Overexpressed TEAD1 and TEAD4 were associated with poor progression-free survival in primary GCs (P o...
Overexpression of TEAD1 and TEAD4 was associated with poor progression-free survival in primary GCs according to GSE14210, GSE15459, GSE22377, GSE29272, GSE51105 and GSE62254 (P<0.001; Figure 1e) by the analysis of Kaplan–Meier plotter (www.kmplot.com).16 Similarly, the abundance of ...
The relative expression of mus musculus (mmu) miR-27a (0.57 ± 0.18, P = 0.016) was significantly lower in the GCs of follicles containing MII oocytes compared with those of MI oocytes 27. Transfection with a mmu-miR-27a-mimic sequence decreased the oocyte maturation rate ...