In vivo, miR-199a increased tumor PTX sensitivity. Conclusions: The downregulation of miR-199a contributes to PTX resistance in prostate cancer. YES1 mediates the regulation of miR-199a in prostate cancer PTX resistance. This miR-199a replacement therapy has potential to o...
gene therapy miR-199a-3p ultrasound-targeted nanobubble destruction liposome nanobubbles Introduction Hepatocellular carcinoma (HCC) is a malignant tumour that seriously threatens human health, manifesting as pain, weight loss, ascites, jaundice and decreased liver function, which may lead to death in ad...
Cancer Cell International (2022) 22:120 https://doi.org/10.1186/s12935-022-02505-1 Cancer Cell International PRIMARY RESEARCH Open Access The regulation of autophagy by the miR‑199a‑5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance Tiezhi...
miR199a-3p is involved in the regulation of cardiac c-kit+cell proliferation and apoptosis.aAnalysis of total RNA to determine the relative expression of miR199a-3p through qRT-PCR in cardiac c-kit+cells at 48 h after treatment with 200 nM angiotensin II (AngII). Expression was normalized ...
表2 婴幼儿增殖期面部血管瘤复发组和无复发组治疗前后血清miR-199a-5p、miR-378a-3p的表达差异 2.3 婴幼儿增殖期面部血管瘤治疗后不同瘤体分级患儿血清miR-199a-5p、miR-378a-3p表达比较 治疗后瘤体分级Ⅲ~Ⅳ级患儿血清miR-199a-5p、miR-378a-3p表达高于Ⅰ~Ⅱ级(P<0.05)(表3)。
These results suggest that miR-199a-5p may play an oncogenic role in gastric cancer by targeting klotho and might serve as a potential therapy target of patients with gastric cancer in future.Change history 14 July 2022 This article has been retracted. Please see the Retraction Notice for more...
It was previously demonstrated that microRNA-199a (miR-199a) was down-regulated in testicular germ cell tumor (TGCT) partially caused by hypermethylation of its promoter. miR-199a is encoded by two loci in the human genome, miR-199a-1 on chromosome (Chr) 19 and miR-199a-2 on Chr 1...
In epithelial cells, miRNA-199a-5p/-3p and Brm, a catalytic subunit of the SWI/SNF complex were previously shown to form a double-negative feedback loop through EGR1, by which human cancer cell lines tend to fall into either of the steady states, types 1 [miR-199a(2)/Brm(1)/EGR1...
治疗前 ,后采集静脉血 ,qRT⁃PCR 检测血清 miR⁃199a⁃5p,miR⁃378a⁃ 3p 表达 ,分析血清 miR⁃199a⁃5p,miR⁃378a⁃3p 表达与增殖期面部血管瘤婴幼儿普萘洛尔停药后复发的关系.结果 无复发组治疗后血清 miR⁃199a⁃5p,miR⁃378a⁃3p 表达较治疗前增高(P<0.05),复发组治疗后血清...
Numerous studies have shown the involvement of microRNAs in tumorigenesis, tumor progres- sion and response to therapy [5, 6]. There is a significant association between miRNA expres- sion profiling and clinical pathological charac- teristics [7]. For instance, miR-199a has been shown to be ...