[0001] 本发明属于生物医学领域,具体涉及一种miR-18a-5p抑制剂在制备防治骨质疏 松药物中的应用。【背景技术】[0002] 骨质疏松症(osteoporosis, 0P)是由多种原因引起的,以单位体积内骨组织量减 少、骨密度降低为标志的全身性、进行性、代谢性骨病。0P分为原发性和继发性两种,原发性 0P又分为I型绝经后0P...
miR-18a-5pNotch2Postmenopausal osteoporosis (PMOP) is a metabolic disorder characterized by the loss of bone density, which increases the risk of developing complications such as fractures. A pivotal factor contributing to the onset of PMOP is the diminished osteogenic differentiation capacity of bone...
使用来自亲代乳腺癌细胞的高度肺转移亚系,miRNA表达谱显示miR-17-92簇显著下调,miR-18a-5p是下调最明显的。异位表达和miR-18a-5p的抑制证明了其抑制乳腺癌细胞迁移和侵袭的能力。进一步研究发现控制脂质代谢的主要转录因子固醇调节元件结合转录蛋白1(SREBP1)是miR-18a-5p的候选靶标。SREBP1过度表达并且与乳腺癌的较...
经过敲降或过表达lncRNA-m18as1后,我们采用RT-qPCR与酶联免疫吸附剂测定(ELISA)分析了lncRNA-m18as1对FshβmRNA以及FSH分泌的调控作用。我们预测并确定了lncRNA-m18as1发挥作用的lncRNAm18as1/miR-18a-5p/Smad2轴。我们使用RNA...
Leonurine-Repressed miR-18a-5p/SOCS5/JAK2/STAT3 Axis ActivityDisrupts CML malignancyHui-Min Liu 1 † , Chun-Ling Guo 2 † , Yao-Fang Zhang 1 , Jian-Fang Chen 1 , Zhi-Peng Liang 3 ,Lin-Hua Yang 1 * and Yan-Ping Ma 1 *1 Department of Hematology, The Second Hospital of Shanxi...
1.miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用,其特征在于:所述miR-18a-5p抑制剂具有如SEQ ID NO.2所示的核苷酸序列片段。 2.根据权利要求1所述的miR-18a-5p抑制剂在制备防治骨质疏松药物中的应用,其特征在于,miR-18a-5p抑制剂通过下调miR-18a-5p的表达,解除miR-18a-5p对LXR-β基因表达的抑制,进而实...
货号:xtr-miR-18a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:xtr-miR-18a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
Cancer Management and Research Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Tumor-educated platelet miR-34c-3p and miR-18a-5p as potential liquid biopsy biomarkers for nasopharyngeal carcinoma diagnosis This article was published in the ...
Cancer Management and Research Dovepress open access to scientific and medical research Open Access Full Text Article ORIGINAL RESEARCH Tumor-educated platelet miR-34c-3p and miR-18a-5p as potential liquid biopsy biomarkers for nasopharyngeal carcinoma diagnosis This article was published in the ...
Aims: To investigate expression levels of TEP miR-34c-3p and miR-18a-5p and determine their diagnostic values for NPC. Materials and methods: Relative quantitative real-time PCR was used to determine the expression levels of TEP miR-34c-3p and miR-18a-5p in NPC patients (n=54) as ...