Resistin facilitates VEGF-A-dependent angiogenesis by inhibiting miR-16-5p in human chondrosarcoma cellsResistin is an adipokine that is associated with obesity, inflammation, and various cancers. Chondrosarcomas are primary malignant bone tumors that have a poor prognosis. VEGF-A is a critical ...
分析原因为miR-195-5p在胰岛素信号转导和胰岛素分泌中起重要作用,其表达上调抑制胰岛素受体表达,损害胰岛素信号转导和糖原代谢[16];miR-195-5p还可通过负调控线粒体融合蛋白2表达,抑制胰岛素受体底物1、2/磷脂酰肌醇-3激酶/蛋白激酶B信...
The study of muscle disorders has gained popularity, with a particular emphasis on the relationship between adipose tissue and skeletal muscle. In our investigation, we discovered that the deletion of miR-146a-5p specifically in adipose tissue (aKO) led
The synthesis of miR-143, the interaction between miR-143 and the target genes to regulate adipocyte differentiation and lipid metabolism, in order to provide new ideas to the diagnosis and treatment for the obesity disease were reviewed. Key words: microRNA miR-143 Target gene Lipid metabolism ...
Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival. Breast Cancer Res Treat. 2014;147(2):381–7. Article CAS Google Scholar Singh J, Deshpande M, Suhail H, Rattan R, Giri S. Targeted Stage-Specific ...
Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity Article Open access 25 June 2024 Metformin selectively dampens the acute inflammatory response through an AMPK-dependent mechanism Article Open access 21 September 2021 Long-term exposure of human...
Tumour-associated macrophages (TAMs) are the most abundant immune cells in the tumour environment and are considered similar to M2 macrophages, which facilitate cancer progression. Exosomes, as important mediators of the cross-talk between tumour cells a
Obesity, 2017, 25(10): 1734-1744 [7] Ng R, Hussain NA, Zhang Q, et al. MiRNA-32 drives brown fat thermogenesis and trans-activates subcutaneous white fat browning in mice. Cell Rep, 2017, 19(6): 1229- 1246 [8] López de Las Hazas MC, Gil-Zamorano J, Cofán M, et al. One-...
Various personal level of risk factors for OA are identified, including genetic predispositions, sociodemographic characteristics such as female sex, diet-related factors, high bone density/mass, and obesity [3]. Knee OA (KOA) is one of the most prevalent degenerative disorders, which results in ...
et al. Adipose tissue microRNAs as regulators of CCL2 production in human obesity. Diabetes 61, 1986–1993, doi: 10.2337/ db11-1508 (2012). 42. Zhang, Y. et al. miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer ...