MiR-133a-3p直接靶向组织内转化生长因子β结合蛋白1 (latent transforming growth factor beta binding protein 1,LTBP1)和蛋白磷酸酶2A催化亚基α (protein phosphatase 2, catalytic subunit, alpha isozyme,PPP2CA)。KEGG分析显示,转化生长因子-β (t
miR-133a-2 位于 20 号染色体上。Dicer 酶对这些前体转录物进行加工，生成成熟的 miR-133a-3p4。
内质网应激抑制剂Salburinal (Sal)和ROS清除剂NAC都可以抑制Bufothionine诱导的GC细胞死亡。此外，Bufothionine可上调miR-133a-3p，过表达的miR-133a-3p可增强Bufothionine诱导的细胞死亡，敲除miR-133a-3p后细胞凋亡显著减少。此外,miR-133a-3p通过胰岛素样生长因子1受体(IGF1R)抑制PI3K/Akt信号通路，同时Bufothionin...
实验证实 miR-133a-3p 能促进心肌细胞和内皮细胞增殖,抑制 PANoptosis。进一步研究发现,miR-133a-3p 通过靶向 ELAVL1 发挥作用,ELAVL1 作为 RNA 结合蛋白,能稳定 NLRP3 mRNA,促进 PANoptosome(参与 PANoptosis 的多蛋白复合物 )形成和 PANoptosis。而 N-EVs 递送的 miR-133a-3p 可抑制 ELAVL1 表达,降低 NLR...
结论血清miR-155-5p和miR-133a-3p可能作为脓毒症诊断的特异性标志物,miR-155-5p可作为影响脓毒症预后的独立危险因素。 关键词: 脓毒症;微小RNA;诊断;预后 ABSTRACT ObjectiveTo explore the value of serum microRNA-155-5p and -133a-3p (miR-155-5p and miR-133a-3p) expression for the diagnosis an...
miR-133a-3p SUMO-specific protease 1 (SENP1) CDK inhibitors 摘要 Dysregulation of SUMO-specific protease 1 (SENP1) expression has been reported in several kinds of cancer, including human colorectal and prostate cancers, proposing SENP1 as an oncogene with a critical role in cancer progression....
MiR-133a-3p overexpression using miRNA mimics was conducted to evaluate its function on ovarian cancer cells. Results We showed that PYGB was upregulated in ovarian cancer tissue and high level of PYGB expression is markedly correlated with poor prognosis of ovarian cancer patients. PYGB ...
说明:gga-miR-133a-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产物的翻译,从而起到转录后调控靶基因的表达。 miRNAs广泛存在于动物、植物、真...
Subsequently, we verified the tumor suppressor role of microRNA-133a-3p in gastric cancer cells through a series biological function assay. We used immunofluorescence and transmission electron microscope to observe the negative effect of microRNA-133a-3p on autophagy and used dual-luciferase report ...