为证明miR-122-5p在运动促进骨骼肌血管新生中的作用,使用了miR-122-5p的体内抑制剂AntagomiR-122-5p,发现小鼠尾静脉注射AntagomiR-122-5p能够抑制运动诱导的骨骼肌VEGF信号激活及血管新生。为了进一步探究循环miR-122-5p的来源,研究人员检...
miR-122-5pCSFerroptosisNasopharyngeal carcinoma (NPC) is a tumor that occurs in the nasopharynx. Although advances in detection and treatment have improved the prognosis of NPC the treatment of advanced NPC remains challenging. Here, we explored the effect of microRNA (miR)-122-5p on erastin-...
在一个具体实施方案中,所述试剂盒包括用于检测mir-122-5p表达量的检测引物和荧光标记的探针。 通过使用本发明提出的外周血中的mir-122-5p表达量作为分子标志,可对肾血管性高血压及其引起的肾脏纤维化损伤进行无创检测,并且对其病变过程进行无创动态监控,具有重要的临床应用价值。 附图说明 图1为小鼠肾脏组织的he染色...
[摘要]背景与目的:miR-122在多种肿瘤中表达异常,参与肿瘤细胞增殖、凋亡等,而cAMP反应元件结合蛋白1(cAMP response element-binding protein 1,CREB1)参与食管癌发展过程,研究miR-122-5p通过靶向CREB1对食管癌细胞及移植瘤生长的作用及机...
122-5p表达的相 关性,并分析二者在不同临床 /病 理参数中的差异,Kaplan-Meier生 存曲线分析不同 lncRNA- SOX2OT,miR-122-5p表达患者预后情况.结果 HCC组织中 lncRNA-SOX2OT表达高于癌旁组织,miR-122-5p表达低于 癌旁组织(t=21.258,20.475,P均 <0.001).HCC组织中 lncRNA-SOX2OT与 miR-122-5p表达呈负...
老年急性冠脉综合征患者中m i R -122-5p 的表达及 与主要不良心血管事件的关系分析* 刘晶晶1,崔璐璐1ә,万 莉1,程 珍2 1.湖北省黄石市第五医院心血管内科,湖北黄石435005;2.湖北省黄石市中医医院急诊科,湖北黄石435000 摘 要:目的 探讨老年急性冠脉综合征(A C S )患者血清微小核糖核酸-122-5p (m ...
过表达CREB1可逆转miR-122-5p 对食管癌细胞和移植瘤增殖和凋亡的影响。结论：miR-122-5p 通过靶向下调CREB1来抑制食管癌细胞增殖，并诱导细胞凋亡，从而抑制食管癌细胞和移植瘤的生长。［关键词］ miR-122-5p ；cAMP 反应元件结合蛋白1；食管癌；增殖；凋亡 DOI: 10.19401/j.cnki.1007-3639.2021.01.005 中图...
miR-122-5pNDRG3APAPDrug-induced liver injuryMiR-122-5p serves as a novel biomarker for drug-induced liver injury (DILI), but its function in DILI remains unclear. The present study, therefore, explored the function and potential mechanism of miR-122-5p in DILI. Sprague-Dawley (SD) rats ...
miR‐122‐5pradiosensitivityCervical cancer is one of the most common gynecological malignancies globally, Unfortunately, radiotherapy and chemotherapy are not effective at treating some cases of this disease, and the 5﹜ear survival rate is only 40%. CDC25A has been shown to induce radio‐...
The 5-year survival rate of non-small cell lung cancer (NSCLC) patients is very low. MicroRNAs (miRNAs) are involved in the occurrence of NSCLC. miR-122-5p interacts with wild-type p53 (wtp53), and wtp53 affects tumor growth by inhibiting the mevalonate