miR-106b-5p靶向调控细胞周期蛋白D1抑制结直肠癌细胞增殖、迁移与侵袭 论 著?基础研究?ｍｉＲ－１０６ｂ－５ｐ靶向调控细胞周期蛋白Ｄ１抑制结直肠癌细胞增殖、迁移与侵袭 方洪生，骆 洋，林海萍，敬 然，秦绍岚，汤佳音，俞 皓，钟 鸣 ｍｉＲ－１０６ｂ－５ｐｉｎｈｉｂｉｔｓｐｒｏｌｉｆｅｒａｔｉｏｎ，...
我们在H‑exo中发现miR‑106b‑5p表达水平上升,由此推测在缺血再灌注损伤微环境中,心肌细胞可能通过外泌体传递miR‑106‑5p到达巨噬细胞,促进巨噬细胞的炎症反应,参与MIRI。为了进一步确认miR‑106b‑5p在巨噬细胞中的作用,我们构建了过表达模型,发现miR‑106b‑5p能够促进巨噬细胞M1型极化的发生,并...
所述miR‑106b‑5p的核苷酸序列为5’‑AUCUGCACUGUCAGCACUUUA‑3’。本发明通过实验发现,miR‑106b‑5p在大动脉粥样硬化型脑梗死患者、心源性栓塞型脑梗死患者和健康正常人血浆外泌体中的表达存在差异,可用于作为鉴别诊断大动脉粥样硬化型脑梗死和心源性栓塞型脑梗死的标志物,具有特异性和敏感性。本...
说明:cgr-miR-106b-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录产物的翻译,从而起到转录后调控靶基因的表达。 miRNAs广泛存在于动物、植物、真...
MicroRNA (miR)-106b-5p is highly expressed in colon cancer; however, data on its expression levels in left-sided colon cancer (LCC) vs. right-sided colon cancer (RCC) is lacking. The present study aimed to assess the differences in miR-106b-5p expression in stage II LCC and RCC, as...
Clinically, low miR-106b-5p expression predicted poor survival of CRC patients, especially in combination with high MALAT1/ SLAIN2 expression. Interpretation miR-106b-5p served as a suppressor in combination with MALAT1/miR-106b-5p/SLAIN2, which might be a group of potential prognostic ...
In particular, miR-106b-5p and miR-200c-3p were expressed at higher levels in patients with ITP compared to the normal controls. Furthermore, these two miRNAs expressions were even higher in patients with chronic ITP. CONCLUSION: MiR-106b-5p and miR-200c-3p may represent valuable ...
RNF2 is regulated by miR17-5p, miR20a-5p and miR106b-5p in breast cancer cell lines Human Gene Volume 39,February 2024, Page 201245 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. ...
miR-106b-5p可能抑制骨质疏松性骨折的发生,并成为潜在的标志物和治疗靶标。 https://orcid.org/0000-0001-5670-4718 (崔泳) 中国组织工程研究杂志出版内容重点:组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程 关键词:骨质疏松性骨折, miR-106b-5p, PI3K-Akt, 转化生长因子β,...