Questions for Discussion 1. What is theminor allele frequencyfor anSNPwith the following genotype frequencies:AA0.64,Aa0.32, andaa0.04? 2. Why is it important to determine the Hardy–Weinberg Equilibrium? 3. What are the advantages and disadvantages of candidate gene and genome-wide approaches fo...
Please see the Supplementary Note 6 for a detailed description of the annotation fields and database versions. Annotated variants mapping to coding or noncoding exonic sequence were further prioritized according to these criteria: (i) sequencing quality; (ii) allele frequency (restricting to rare ...