AI Proteins, Inc., a biotechnology company that utilizes computational de novo protein design to create therapeutic miniproteins, announced that it has entered a Research Collaboration and Option Agreement with Bristol Myers Squibb to discover and develop novel ...
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8 Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres Fernandez, John C. Kraft, Jing Li, Viet Q. Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, P. Daniel Pouls...
et al. A miniprotein scaffold used to assemble the polyproline II binding epitope recognized by SH3 domains. J. Mol. Biol. 342, 355–365 (2004). Article CAS PubMed Google Scholar Velankar, S. et al. PDBe: Protein Data Bank in Europe. Nucleic Acids Res. 38, D308–D317 (2010). ...
Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein Protein-protein interacting surfaces are usually large and intricate, making the rational design of small mimetics of these interfaces a daunting problem. ... C Vita,E Drako...
Based on MSA-MD, we can detect a wider conformational space of a peptide or miniprotein through large scale structure sampling. And the near native conformations of the pepides and proteins can be obtained. A conformational ensem- ble which is close to the protein native crystal structure can...
A correction to the article "All-Atom Level Direct Folding Simulation of a ββα Miniprotein" is presented. S Jang,E Kim,Y Pak - 《The Journal of Chemical Physics》 被引量: 22发表: 2008年 All-atom level direct folding simulation of a beta beta alpha miniprotein The Journal of Chemical...
Impens, F., Rolhion, N., Radoshevich, L.et al.N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation inListeria monocytogenes.Nat Microbiol2, 17005 (2017). https://doi.org/10.1038/nmicrobiol.2017.5 ...
A fast method for large-scale De Novo peptide and miniprotein structure prediction 2010. A fast method for large-scale de novo peptide and miniprotein structure prediction. J. Comput. Chem. 31:726 -738. J Maupetit,P Derreumaux,P Tufféry - 《Journal of Computational Chemistry》 被引量: 160...
Peptides (< 25 residues) rarely have well-defined, deep energy wells for folding with the possible exception of a reported few hairpin and miniprotein structures. However, these systems display relatively low melting temperatures and broad thermal transitions for unfolding. Our lab has recently employ...
www.nature.com/scientificreports OPEN Proteoliposomal formulations of an HIV-1 gp41-based miniprotein elicit a lipid-dependent received: 24 August 2016 immunodominant responseaccepted:12December2016 Published:13January2017 overlapping the 2F5 binding motif Luis M. Molinos-Albert1, Eneritz Bilbao2...