Mini-protein binders are small globular proteins consisting of 37–65 amino acids40,41,42,43,44,45. They have been specifically designed with surface residues that allow for the formation of shape- and chemical-complementary interactions with the structural epitope on the target molecule. The mini...
De novo design of broad-spectrum mini-protein binders against the RBI-1 of TcdB We aimed to design pan-specific mini-protein binders that would target the RBI-1 of clinically dominant TcdBs. According to the previous study, the RBI-1 can be divided into two classes: the class I RBI-1 ...