Encouragingly, we establish the capacity of our model to uncover in vivo activity for the biotin biosynthesis inhibitor MAC13772. Our model addresses the disconnect in biotin levels between humans and mice, and explains the failure of potent biotin biosynthesis inhibitors in standard mouse infection ...
The implementation of these options has forged novel pathways for applications in diverse fields such as molecular engineering, nanotechnology, sensing modules, electrochromism, non-volatile memory devices, photocatalysis, and solid-state devices, among others (Fig. 2). In this context, the present ...
In-depth, qualitative interviews (n = 4) and focus group discussions (FGDs) (n = 23) were conducted with women who had concurrently experienced a state of homelessness and mental illness, and accessed one or more institutional and quasi-institutional services...
Se represents the proportion of epitope aa present in the peptide, whereas PPV is the proportion of peptide aa present in the epitope. The aa nature or the aa position in the peptide and reference epitope was then compared by not taking and by taking into account the aa positions of the ...
We therefore developed a class of imidazolium-based lipids including cholesterol analogs that integrate into model and cellular membranes9,10,11,12,13,14. These include cholesterol analogs (Fig.1), herein referred to as CHIM (for CHolesterol-based IMidazolium salt), in which the hydroxyl group of...
grown spiral helical nanoribbons have been observed between walls (the bright white part represents the wall of nanotube). The nanoribbons between the top and bottom appear to have a winding effect at the spiral parts. The plausible structure of Ni-IH-7 was predicated with using AlphaFold2 ...
Fasting-mimicking diets delay tumor progression and sensitize a wide range of tumors to chemotherapy, but their therapeutic potential in combination with non-cytotoxic compounds is poorly understood. Here we show that vitamin C anticancer activity is lim
Similar content being viewed by others Enhanced dengue vaccine virus replication and neutralizing antibody responses in immune primed rhesus macaques ArticleOpen access21 May 2021 Prior flavivirus immunity skews the yellow fever vaccine response to cross-reactive antibodies with potential to enhance dengue ...
(GM) polysaccharide modified with acetyl groups (acGM) represents the essential, PAMP-mimicking structure to generate macrophages with anti-tumor activities. In this design, GM offers repeating units of glucose and mannose, and acetylation adds the simplest possible aliphatic group to the sugar ring....
Similar content being viewed by others Introduction For decades, the use of synthetic herbicides in agriculture has been raising concerns about public health and environmental preservation1,2,3. Additionally, herbicides could become increasingly less effective as weeds develop resistance to the commonly us...