5-ASA, a first-line treatment for mild to moderate UC, must be taken several times daily, an inconvenience that may cause patients to skip doses, according to Dr. Sandborn, a professor of medicine at the Mayo Clinic College of Medicine in Rochester, Minnesota. "High pill burden has been...
doi:10.1001/archneurol.2012.2194 Abstract Objective To assess the safety, tolerability, and pharmacokinetic and pharmacodynamic effects of the γ-secretase inhibitor avagacestat in patients with mild to moderate Alzheimer disease (AD). Design Randomized, double-blind, placebo-controlled, 24-week phase ...
We aimed to elucidate the complement of the gut- microbiome community and its relationship with burden of disease measures in a population of individuals with bipolar disorder. Methods: We compared the stool microbiome from individuals with bipolar disorder (n = 115) and control subjects (n = 64...
to-moderate PD and healthy controls. Participants included nine individuals with PD and nine age- and gender-matched controls (CON). This study examined margin of stability metrics using instrumented 3D motion analysis during the two-step sequence of the obstacle-crossing task. Dynamic balance ...