female athletes may take longer to become symptom free following sports-related concussion84. Taken together, this demonstrates sex differences following recovery from TBI and substantiates the importance of using both sexes in preclinical animal models. Interestingly, sex-dependent differences in function ...
Previous work has shown that ApoE plays an important part in brain recovery after injury due to its support of neuronal repair mechanisms64,65,66. After injury, ApoE has been shown to play a role in the recovery of the blood brain barrier (BBB)67, the clearance of neurotoxic fragments68, ...
Mild traumatic brain injury (mTBI), or concussion, accounts for 85% of all TBIs. Yet survivors anticipate full cognitive recovery within several months of injury, if not sooner, dependent upon the specific outcome/measure. Recovery is variable and deficits in executive function, e.g., working ...
to a new injury if they had sustained two before as shown by a cohort study performed by the National Athletic Association NCAA, on 4251 players, suggesting that the likelihood to have a future concussion increases with players having a history of insults that slow down their recovery time4. ...
Atypical proliferation and migration of immature neurons to the outer granule layer of the dentate gyrus and hilus occurs in several models of single moderate TBI22,23, however, it remains unclear whether these TBI-induced changes are model dependent, benefit recovery from injury or mediate the est...