(2002). Brain atrophy in mild or moderate traumatic brain injury: a longitudinal quantitative analysis. AJNR Am J Neuroradiol 23: 1509-1515.MacKenzie, J. D., Siddiqi, F., Babb, J. S., Bagley, L. J., Mannon, L. J., Sinson, G. P., et al. (2002). Brain atrophy in mild or...
Chronic sleep deprivation disrupts circadian rhythms and neurochemical pathways, potentially accelerating brain atrophy, while physical exercise preserves brain structure by enhancing vascular health, reducing inflammation, and supporting synaptic plasticity, particularly in regions like the hippocampus. Results ...
Atrophy patterns on MRI can reliably predict three neuropathological subtypes of Alzheimer's disease (AD): typical, limbic-predominant, or hippocampal-sparing. A method to enable their investigation in the clinical routine is still lacking. We aimed to (1) validate the combined use of visual ...
43 First, a TBI can damage brain structure as a direct result of the injury.43 Diffuse axonal injury is common in all severities of TBI.44,45 Autopsy and neuroimaging studies also have shown that a single moderate to severe TBI can cause marked cerebral atrophy 6 months postinjury that may...
greater decline in the ability to perform complex tasks, which on brain scans was associated with atrophy in crus II, an area of the cerebellum associated with cognition Compared with the control group, volunteers with a prior SARS-CoV-2 infection had an additional 0.2% to 2% gray matter loss...
Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer’s disease Nuanyi Liang, Kwangsik Nho, John W. Newman, Matthias Arnold, Kevin Huynh, Peter J. Meikle, Kamil Borkowski, Rima Kaddurah-Daouk & the Alzheimer...
Alzheimer's disease (AD) is associated with atrophy in entorhinal cortex (ERC), the hippocampus, and its subfields Cornu Ammonis 1 (CA1) and subiculum, which predict conversion from mild cognitive impairment (MCI) to clinical AD. The stratum radiatum, lacunosum, and moleculare (SRLM) are ...
Solanezumab is a humanized monoclonal antibody that preferentially binds to soluble amyloid β and promotes its clearance from the brain in preclinical studies. The objective of this study was to assess the effect of solanezumab in slowing global and anatomically localized brain atrophy as measured by...
that losartan did not penetrate the blood-brain barrier as much as anticipated; therefore, although peripherally active, as seen by the reductions in blood pressure in the losartan group, it was not able to act more directly in the brain where it was intended to reduce disease-related atrophy...
Lifshitz J, Kelley BJ, Povlishock JT (2007) Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death. J Neuropathol Exp Neurol 66(3):218–229 Article PubMed Google Scholar Lipton ML, Gellella E, Lo C, Gold T, Ardekani BA, Shift...