综上,揭示受体激酶MIK2对不同植物细胞因子家族的感知,确定MIK2是植物细胞因子SCOOP家族的受体。SCOOP12直接与MIK2结合,诱导MIK2-BAK1复合物的形成和下游信号的激活。SCOOP-MIK2配体-受体模块的特征是我们在理解植物细胞感知植物细胞因子的机制方面取得的重大进展。鉴于MIK2的多种生理功能,将SCOOP确定为MIK2配体将有助...
SCOOPMIK2ArabidopsisPlants synthesize hundreds of small secretory peptides, which are perceived by the receptor-like kinase (RLK) family at the cell surface. Various signaling peptide-RLK pairs ensure plant adaptation to distinct environmental conditions. Here, we report that SERINE RICH ENDOGENOUS ...
Accordingly, the SCOOP12 peptide directly binds MIK2 and triggers complex formation between MIK2 and the BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) co-receptor. MIK2 is required for resistance to the important root pathogen Fusarium oxysporum . Notably, we reveal that Fusarium ...
近日,苏黎世大学Cyril Zipfel团队在Nature Plants发表了题为A peptide-receptor module links cell wall integrity sensing to pattern-triggered immunity的研究论文,揭示了一对小肽-受体(SCOOP18-MIK2)模块调控植物细胞壁完整性感知和模式触发免疫PTI(pattern-triggered immunity)反应的分子机制。 该研究通过整合转录组学...
SCOOP signature peptides trigger immune responses and altered root development in a MIK2-dependent manner with a sub-nanomolar sensitivity. SCOOP12 directly binds to the extracellular leucine-rich repeat domain of MIK2 in vivo and in vitro, indicating that MIK2 is the receptor of SCOOP peptides...
Accordingly, the SCOOP12 peptide directly binds MIK2 and triggers complex formation between MIK2 and the BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) co-receptor. MIK2 is required for resistance to the important root pathogen Fusarium oxysporum . Notably, we reveal that Fusarium ...