Movies of 1-min length were recorded while cells were positioned right in the middle of the constrictions, at a frame rate of 200 ms, which is several orders of magnitude faster than the cell migration time
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Forming proneuromasts at the trailing edge decelerate, causing the tissue to stretch, before being deposited (Movie S1). The scale bar is 100 μm. (D and E) Many cells of the primordium display cellular extensions (compare [D] to [E]; Movies S2 and S3). (F) Kymograph analysis of ...
4L, Supplementary Movie 1), identifying uni-lateral cell intercalations as one of the cellular mechanisms underlying hatching gland morphogenesis (Fig. 4M). Download: Download high-res image (2MB) Download: Download full-size image Fig. 4. Hatching gland cells undergo intercalations driving the ...
Migration of meiosis-I (MI) spindle from the cell center to a sub-cortical location is a critical step for mouse oocytes to undergo asymmetric meiotic cell division. In this study, we investigate the mechanism by which formin-2 (FMN2) orchestrates the in
Reducing integrin binding partially rescued 3D cell migration in large-pore gels (FB), allowing cells to slip through the matrix (Fig. 7c,e, and Supplementary Movie 10), while HR still demonstrated reduced migration consistent with pore size dependence. Altogether, these data suggested a ...
Full size image Next, we sought to tune the intracellular diffusion rate by changing molecular crowding in cells via the osmotic pressure48,51. The addition of PEG 300 in the medium would increase the external osmotic pressure. To match the external osmotic pressure, the cell volume decreases ...
Full size image Fig. 3: X-ray Computed Tomography of omphacitite core (size of sample: 5.2 mm height, 3.9 mm diametre). a,bXRM highlights a pervasive network of interconnected fractures. The fractures are sealed by jadeite, garnet, omphacite 2 and graphite. Albite partially replaces...
Full size image The migratory behaviour and the associated dynamics of force exertion of WT and Ex6KO cells were then investigated by taking time-lapse measurements of phase contrast and ERISM displacement maps in 5-min intervals over a time span of 17 h (MoviesS1,S2). The average speed of...
Full size image In contrast to wild-type, cells in the β-PixΔEpi mesoderm were tightly packed (Fig. 4e, f and Supplementary Movie 9). Protrusions in wild-type cells to neighboring epithelia were thin, filopodia-like and highly dynamic (Fig. 4g and Supplementary Movie 10). In contrast...