sleep inducing, and muscle relaxant properties and powerful anterograde amnestic action similar to that of diazepam but not that of lorazepam, whose amnestic action is slow and prolonged. Seven to 9 hours following
although this possibility cannot be excluded. In the doses administered, equivalent to 21 mg of diazepam and 10 mg of midazolam for the typical 70-kg adult male, such a response might be expected. Since publication of this study in 1980, it has been demonstrated that equipotent doses of ...
All doses are given in terms of the base; midazolam hydrochloride 8.3 mg or midazolam maleate 10.2 mg are both equivalent to about 7.5 mg of midazolam. A usual total sedative dose for dental and minor surgi- cal and other procedures ranges from 2.5 to 7.5 mg (about 70 micrograms/kg) ...
Seven to 9 hours following midazolam, patients feel more awake and have better psychomotor performance than after an equivalent dose of diazepam or lorazepam. When used in higher dosage for induction of anaesthesia, there is considerable interindividual variation in response, especially in the young. ...
However, in studies limited to children, midazolam (IV or IM) is equivalent to IV lorazepam for the same outcomes (SOR: B, 2 small RCTs). IM midazolam is recommended in adults without pre‐established IV access, but either midazolam or lorazepam are ...
Ultrafiltration clearance was 0.31 L/h, equivalent to approximately 5% of total clearance. Average degree of plasma protein binding was 82.9% for lorazepam, with a sieving coefficient of 0.16 ± 0.03. For lorazepamglucuronide, degree of plasma protein binding was 39.5%, and sieving coefficient was...
(2003) administered midazolam intranasally in epilepsy patients at dosages of 5 and 10 mg/patient (equivalent to about 0.06 and 0.12 mg/kg, respectively), using the midazolam formulation of Knoester et al. (2002a, 2002). Maximum plasma concentrations of 73 and 140 ng/ml are reached in 5...