KammBoxenbaumH.KastrissiosTrapnellC.King A, Laurie R, Connolly M, et al. The effect of rifaximin on the phar- macokinetics (PK) of single doses of intravenous (IV) and oral (PO) midazolam in healthy volunteers (abstract). Clinical Pharmacol Ther 2004;75:P66....
Introduction: Rifaximin (RFX) is a broad-spectrum, poorly absorbed, rifamycin S derived antibiotic being developed to treat traveler's diarrhea. Objective: To evaluate the effect of RFX on the PK of IV and PO midazolam (MDZ), a CYP 3A probe. Methods: An open label, randomized, crossover ...