在胶质母细胞瘤中与PTEN拷贝数相关性最强的前4个microRNA中有3个为miR-29a(pcc=0.219)、miR-29c(pcc=0.260)和miR-29b(pcc=0.228)。打开箭头指示miR-29a表达式配置文件的位置。 图3:miR-29a促进缺乏PTEN的胶质母细胞瘤细胞的增殖和生长。 a)BrdU增殖实验的荧光显微照片(左图)和数据定量(右图),研究慢病毒介导...
MicroRNA-29a-3p是一种小型非编码RNA,广泛参与调节细胞增殖、凋亡和纤维化过程,特别在多种疾病如心脏病、肝纤维化和肿瘤中发挥重要作用。人间充质干细胞外泌体是由人类间充质干细胞分泌的纳米级囊泡,携带RNA、蛋白质和脂质,能够参与细胞间的通讯、组织修复、免疫调节和抗炎等生物学过程。负载MicroRNA-29a-3p的人...
MicroRNA-29a-3p是一种小型非编码RNA,广泛参与调节细胞增殖、凋亡和纤维化过程,特别在多种疾病如心脏病、肝纤维化和肿瘤中发挥重要作用。人间充质干细胞外泌体是由人类间充质干细胞分泌的纳米级囊泡,携带RNA、蛋白质和脂质,能够参与细胞间的通讯、组织修复、免疫调节和抗炎等生物学过程。负载MicroRNA-29a-3p的人...
MicroRNA 29a (miR-29a) is a tumor suppressor miRNA that inhibits cancer cell growth and tumor progression in non-small cell lung cancer. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), which plays an important role in lung cancer progression, has been identified as a target...
MicroRNA is known to regulate tissue remodeling; however, its role in the development of osteoporosis remains elusive. In this study, we uncovered that silencing miR-29a expression decreased mineralized matrix production in osteogenic cells, whereas osteoclast differentiation and pit formation were up...
目的:探讨microRNA-29a(miR-29a)对大鼠心肌细胞(CM细胞)B细胞白血病/淋巴瘤-2(Bcl-2)和髓样细胞白血病-1(Mcl-1)表达的调控机制.方法:体外培养新生Sprague-Dawley大鼠CM细胞和人胚肾细胞株293T.合成大鼠miR-29a的拟似物(mimic)和抑制剂(inhibitor).用脂质体Lipofectamine RNAiMAX转染miR-29a mimic进入CM细胞,...
Therefore, we demonstrate that miR-29a plays a suppressive role in NSCLC via targeting LASP1, suggesting that the miR-29a/LASP1 axis may become a promising therapeutic target for NSCLC. 展开 关键词: non-small cell lung cancer microRNA-29a LIM and SH3 protein 1 proliferation migration invasion...
MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease Neal L. Millar, Derek S. Gilchrist, Moeed Akbar, James H. Reilly, Shauna C. Kerr, Abigail L. Campbell, George A. C. Murrell, Foo Y. Liew, Mariola Kurowska-Stolarska & Iain B. McInnes Nature Communi...
Durable Epigenetic Reprogramming of Exhausted CD8 T cells by MicroRNA-29a doi:10.4049/jimmunol.212.supp.1101.5922Chronic antigen stimulation causes T cell exhaustion. Exhausted CD8 T cells (TEX) have unique transcriptional and epigenetic profiles. Immunotherapy, including 伪PD-1, partially reinvigorates...
miR-122a.microRNA-29a(miR-29a),目前人类最感兴趣的miRNAs家族的一员,研究证实,miR-29a在很多不同类型的肿瘤中如前列腺癌,肾细胞癌,胃癌和胰腺癌是不表达或者是表达下调的,然而miR-29a在HCC中的作用还不清楚.基于上述研究,我们推测,miR-29a可能在HCC的发生发展中起到一定作用.为此我们利用Realtime PCR对肝癌...