Our study revealed that polymeric microneedle-mediated transdermal delivery of melittin could serve as a new therapy with high compliance and good therapeutic efficacy for RA and other autoimmune diseases.doi:10.1016/j.jconrel.2021.07.005Guangsheng Du...
Positively charged nanoparticles tend to demonstrate higher cellular uptake due to the negative charge on cell membranes, but also exhibit higher non-specific binding and potential toxicity [111]. Analogously, negatively charged or neutral nanoparticles can have prolonged circulation time and reduced non-...
For instance, the combination of the delivery model of insulin with glucose kinetics can be used to explore the application of microneedles in diabetes therapy. The mathematical model employed in this study is developed to describe the key delivery processes in transdermal drug delivery using hollow ...
Eight weeks later, angiogenesis and neural stem cell proliferation and migration were assessed. GelMA MN implantation did not elicit an obvious inflammatory response and had good biocompatibility in the brain. AAV-green fluorescent protein (GFP)-loaded MNs could achieve successful transfection and ...
The tip diameter and the drug's injection velocity are thought to serve as regulatory parameters for the effectiveness and efficacy of MN-mediated therapy if the MN is robust enough to sustain the force needed to penetrate a wider tip into the skin.Tanmoy Bhuimali...
The high bioavailability and sustained release with lower doses will not only reduce the side effects but also reduce the cost of therapy and patient compliance. Author Contributions: Conceptualization, T.H. and F.N.; methodology, T.H. and F.N.; validation, M.A.K. and S.P.; formal ...
However, there are limitations such as local and targeted delivery have hampered the successful translation of IL-4 therapy. In this study, we created an IL-4 microparticle-loaded microneedle patch (IL-4 MP-MN) for localized delivery of IL-4 to the MI region and tested the therapeutic ...
First, the skin piece was mounted on a Franz cell containing 5 mL of 1X PBS in the receptor compartment. Then, 300 μL of 1X PBS was added to the donor chamber, and the skin tissue was kept for equilibra- tion for 15 mins. After that, the silver wire was placed in the receptor...
The tip diameter and the drug's injection velocity are thought to serve as regulatory parameters for the effectiveness and efficacy of MN-mediated therapy if the MN is robust enough to sustain the force needed to penetrate a wider tip into the skin....
The tip diameter and the drug's injection velocity are thought to serve as regulatory parameters for the effectiveness and efficacy of MN-mediated therapy if the MN is robust enough to sustain the force needed to penetrate a wider tip into the skin.Tanmoy Bhuimali...