Microbiota I-Center (MagIC) serves as a hub for interdisciplinary collaboration, bringing together microbiome researchers, industry partners, and healthcare professionals. Together, we translate scientific discoveries into practical applications, driving
Microbiota I-Center (MagIC), Shatin, Hong Kong S.A.R., China. siewchienng@cuhk.edu.hk.Nature reviews. Gastroenterology & hepatologyMiyamae M, Kaneda K, Domae N, Figueredo VM: Cardioprotection by regular ethanol consumption: potential mechanisms and clinical application. Curr Drug Abuse Rev; 3...
2C–I). Fig. 2 The gut microbiota mediated the neuroprotective effect of melatonin in memory impairment induced by sleep deprivation. A Schematic illustration of experimental design. B Comparison of bacterial colony-forming unit (CFU) in feces from control- and Abs-treated mice (n = 10)....
In addition, LCA supplementation altered the distribution of intestinal T-cell populations and resulted in significantly enriched CD8+ CTLs, and in vivo and in vitro experiments showed that LCA increased SLA-I expression in porcine intestinal epithelial cells via FXR receptors, thereby recruiting CD8+...
Fig. 1: Humid heat environment causes anxiety-like behaviour and disrupts the cortical E/I balance in mice. a Male mice were randomly divided into the HHE and NC groups (n = 12 mice/group), and the experimental design is illustrated in the schematic overview. HHE humid heat environment...
We acknowledge the staff of the INRAE Infectiology of Fishes and Rodents Facility (IERP-UE907, Jouy-en-Josas Research Center, France) and Micalis axenic animal facilities (ANAXEM) in which animal experiments have been performed. IERP facility belongs to the National Distributed Research ...
To directly address the role of PORCN, we next adopted the PORCN inhibitor (i.e., Wnt-C59). Treatment with Wnt-C59 completely inhibited SI organoid growth induced by lactate alone or by lactate and intestinal stromal cells (Figure S6A). By use of in situ hybridization staining, we ...
i, KEGG enrichment analysis of the genes increased in Sa vs. Con-FMT in mouse small intestine samples. j, KEGG enrichment analysis of the genes increased in Sa vs. A10-FMT in mouse small intestine samples. k, KEGG enrichment analysis of the genes increased in Sa vs. A100-FMT in mouse ...
in iTreg cells (Fig.3h), while the mRNA level of HIF-2α was not increased (Suppl. Fig. S7c). Given the presence of IREs in the 5’UTR of HIF-2α45, the activity of the HIF-2α 5’-UTR in iTreg cells was substantially enhanced by iron stimulation (Supplementary Fig. S7d), ...
(Figure 1I). Furthermore, histological analysis revealed that the lipid droplet area in the liver was reduced after SA treatment (Figure 1J,K). Meanwhile, food intake was slightly increased in theSA-treated group than in controls (Figure 1L). Collectively, these results indicate that ...