Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect and cleave invader nucleic acids using complementary guides and the nuclease activities of pAgo or Cas proteins. However, not all pAgos are active nucleases. A large clade of short pAgos bind nucleic acid guides...
The study of immunology led to the growth of medical microbiology, which deals with identification, and mechanism of action of infectious agents. The disease-causing organisms are called pathogens and their mode of attacking the host and its effects on host is pathogenesis. The major human pathogen...