Conclusions Autophagy protects lung adenocarcinoma cells from Src-TKIs via a newly identified miR-106a-ULK1 signaling pathway. The combined inhibition of Src and ULK1/autophagy might represent a promising treatment option for future clinical trials. Lastly, our data might challenge the term "oncogenic...
lipids and nucleotides17,18. The degradative substrates in the extracellular space or at the plasma membrane are delivered to lysosomes by the endocytic pathway, whereas the ones in the cytosol reach lysosomes by a mechanism designated autophagy19. There exist at least ...
the innate immune signaling pathway to induce the type I interferon response upon the emergence of cytosolic dsDNA. Cyclic GMP-AMP (cGAMP) synthase (cGAS) directly binds to the cytosolic dsDNA, and the enzymatic activity is upregulated by the binding. Activated cGAS generates cGAMP from ATP and...
et al. MicroRNA-124a/Sirtuin 1 pathway inhibits autophagy to promote hepatocyte apoptosis in acute-on-chronic liver failure. Mol Biol Rep 52, 314 (2025). https://doi.org/10.1007/s11033-025-10373-x Download citation Received15 November 2024 Accepted17 February 2025 Published15 March 2025 DOI...
reported microcolin B/VT01454 as an inhibitor targeting PITPα/β to activate the Hippo/YAP pathway and suppress the proliferation of YAP-dependent tumour cells.38,39 It was more distinct to reveal that PITPα/β are potential targets for cancer therapy. Microcolins are a family of compounds...
With its constitutive characteristics, microautophagy of soluble substrates can be induced by nitrogen starvation or rapamycin via regulatory signaling complex pathways. The maintenance of organellar size, membrane homeostasis, and cell survival under nitrogen restriction are the main functions of micro...
PI4P-signaling pathway for the synthesis of a nascent membrane structure in selective autophagy. J. Cell Biol. 2006, 173, 709–717. [Google Scholar] [CrossRef] [PubMed] [Green Version] Bhaskara, R.M.; Grumati, P.; Garcia-Pardo, J.; Kalayil, S.; Covarrubias-Pinto, A.; Chen, W....
The mTOR signaling pathway is involved in chondrocyte autophagy. The critical pathological features of OA cartilage include the activation of mTOR pathway, repression of chondrocyte autophagy, reduced chondrocyte viability, elevated apoptosis, and lessened surviving chondrocyte quantities [35, 36]. ...
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The cardioprotection of the insulin-mediated PI3K/Akt/mTOR signaling pathway. Am J Cardiovasc Drugs. 2014;14:433–42. Article CAS Google Scholar Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, et al. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2....