researchers from Osaka University and Nara Prefectural Medical University in Japan have demonstrated for the first time that damaged lysosomes can be repaired through the micro autophagy mechanism, and identified two key regulatory factors in this process, ...
Unexpectedly, we found that glucose limitation also causes proteasomes to be taken up directly into vacuoles by a microautophagy mechanism. Macro- and micro-autophagy occur in parallel in glucose-starved cells, and microautophagy appears biased toward aberrant or inactive proteasomes, leaving ...
摘要| ‘自噬’是指细胞内容物(如受损细胞器和蛋白质聚集体)被运送到溶酶体进行降解的一种进化保守过程。根据底物的性质和将其运送到溶酶体的方式,人们描述了不同形式的自噬。目前,哺乳动物细胞的自噬主要分为巨自噬、微自噬和分子伴侣介导的自噬。人们对巨自噬和伴侣介导的自噬的分子机制和生物学功能进行了广泛的研...
Understanding of the mechanism that underlies the cooperation of these two autophagic processes will lead to deciphering their distinct and general roles in cellular catabolic processes. Outstanding questions How are the targets of lysosomal microautophagy determined? What makes the difference between the ...
While it has been reported that miR-152-3p promotes the apoptosis of ovarian cancer cells,Citation44 but there is no report on the involvement of miR-152-3p in the resistance mechanism of ovarian cancer to PTX. In the present study study, online gene databases (miRDB, miRwalk, TargetScan ...
This microautophagy-like mechanism transports cytosolic proteins into LE but not lysosomes in a chaperone-dependent manner. This process does not require substrate unfolding or the essential component of CMA in lysosomes, LAMP-2A, but it relies on electrostatic binding of hsc70 to endosomal acidic ...
Autophagy (which includes macro-, micro-, and chaperone-mediated autophagy) is an important biological mechanism for degradation of damaged/obsolete macrom... Y Stroikin,H Dalen,S L??F,... - 《European Journal of Cell Biology》 被引量: 190发表: 2004年 Tubulin polymerization-promoting protein...
2011). Our finding that TORC1 prevents microautophagic degradation of the v-ATPase subunit Vph1, therefore, indicates the existence of a positive feedback control mechanism that may contribute to the robustness of TORC1 signaling. The degradation of Vph1-GFP upon inhibition of TORC1, however, ...
3. Mechanism After signaling, nucleophagic processes begin with the formation of micronuclei. These small portions of nuclear material are then recognised by the autophagic machinery. Their formation has not yet been described in detail. Recruitment of the autophagic machinery to micronuclei most likely...
This study was to investigate the underlying mechanism by which Saikosaponin D (SSD) mitigates the inflammatory response associated with osteoarthritis (OA) and regulates autophagy through upregulation of microRNA (miR)-199-3p and downregulation of transcription Factor-4 (TCF4). Methods A mouse OA ...