Micro MIRThe present invention relates to very short heavily modified oligonucleotides which target and inhibit microRNAs in vivo, and their use in medicaments and pharmaceutical compositions.スサンナオバドサカリカウッピネンヨアシムエルメン
由于p53缺陷、表观遗传沉默和基因组缺失的改变,microRNA miR-34a是临床最相关的肿瘤抑制microRNA之一。美国普渡大学研究人员合成了miR-34a的完全修饰版本(FM-miR-34a),提高稳定性而不影响其活性,克服稳定性差、非特异性递送和递送相关毒,有望让大量癌症患者从miR-34a替代中受益。 研究摘要 癌症几乎可以发生在人体...
[MicroMir]1/144 B-2 只看楼主收藏回复 aszx175 口模 14 送TA礼物 1楼2018-07-22 17:16回复 СукаБаиду 堆积如山 13 不会是把馊膜哥的拿来缩比吧 来自Android客户端3楼2018-07-22 18:05 回复 he112 口模 14 照电影开的? 来自iPhone客户端5楼2018-07-22 19:20 回复 ...
We examined expression profiles of 16 micro RNAs (miRNAs) in triple negative breast cancers to identify their potential as biomarkers for lymph node metastasis. The expression profiles of miR-9, miR-21, miR-30a, miR-30d, miR-31, miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a...
MicroRNA-1 is a candidate tumor suppressor and prog- nostic marker in human prostate cancer. Nucleic Acids Res. 2012;40(8):3689-703... RS Hudson,M Yi,E Dominic,... - 《Nucleic Acids Research》 被引量: 241发表: 2011年 miR-30c-1* promotes natural killer cell cytotoxicity against human...
Hundreds of bioinformatics tools have been developed for MicroRNA (miRNA) investigations including those used for identification, target prediction, structure and expression profile analysis. However, finding the correct tool for a specific application requires the tedious and laborious process of locating,...
MicroRNA hsa-miR-4717-5p regulates RGS2 and may be a risk factor for anxiety-related traits 来自 Wiley 喜欢 0 阅读量: 51 摘要: Regulator of G-protein Signaling 2 (RGS2) is a key regulator of G-protein-coupled signaling pathways involved in fear and anxiety. Data from rodent models and...
A newly identified microRNA, mmu-miR-7578, functions as a negative regulator on inflammatory cytokines tumor necrosis factor-α and interleukin-6 via targe... Zhang J;Xie S;Ma W.A newly identified microRNA,mmu-miR-7578,functions as a negative regulator on inflammatory cytokines tumor necrosis ...
Lastly, we determined that ame-miR-279a directly target the mRNA of Mblk-1. These findings suggest that ame-miR-279a plays important roles in regulating honey bee division of labour 展开 关键词: microRNA Honey bee Proboscis extension reflex Sucrose responsiveness Division of labour ...
We found upregulation of expression of the microRNA miR-155 in primary effector and effector memory CD8(+) T cells, but low miR-155 expression in naive and central memory cells. Antiviral CD8(+) T cell responses and viral clearance were impaired in miR-155-deficient mice, and this defect...