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At 2 dpi, infectious virus levels in the nasal turbinates and lungs were significantly lower (≈1,000-fold, P < 0.001) in BALB/c mice infected with B.1.1.529 compared to B.1.351 (Fig. 1d). We used whole-body plethysmography35 to measure pulmonary function in infected mice. At...
K. et al. Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2−/−γc−/− mouse. J. Virol...
In general, newborn mice are most susceptible to clinical disease and to lethal infection and develop higher levels of resistance with increasing age. Infection of neonates leads to abnormal brain development [27], [28]. Virus replication is observed in newborn mice in many tissues and appears ...
A new nanoparticle vaccine for SARS-CoV-2, the virus that causes COVID-19, has shown hints of protection and immunity by safely eliciting the production of antibodies and antiviral T cell responses in mice and pigtail macaques, according to a new preclin
Designed computationally and refined in the laboratory, the new protein therapies thwarted infection by interfering with the virus' ability to enter cells. The top protein neutralized the virus with similar or greater potency than antibody treatments with Emergency Use Authorization status from...
a new study published in the journal Molecular Therapy, researchers at Temple University and the University of Pittsburgh reported performing the feat in three different animal models, including a "humanized" model in which mice were transplanted with human immune cells and infected with the virus. ...
transplanted ES cell-derived germ cell co-aggregated with wild type newborn ovarian tissue into the kidney capsule of recipient mice and found that the ovarian niche could direct functional maturation of these germ cells [9]. Similarly, isolated female germline stem cells from neonatal mouse ...
et al. Experimental infection of NOD/SCID mice reconstituted with human CD34+ cells with Epstein–Barr virus. J. Virol. 78, 13891–13900 (2004). Article CAS PubMed PubMed Central Google Scholar Kneteman, N. M. et al. Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes ...
In western North America, breathing dust that has come in contact with mouse feces has been linked to the deadly hantavirus.[citation needed]. The original motivation for the domestication of cats is thought to have been for their predation of mice and their relatives, the rats.[citation ...