Several studies reported non-monotonic effects of endocrine disrupters exhibiting estrogenic activity, similar to those triggered by endogenous hormones, with more effects observed at low relevant doses58. For instance, we previously described a non-monotonic response on male behavior induced by adult ...
Here we systematically tested the addictive properties of sugar in male and female mice using established paradigms and models from the drug addiction field. (i) We applied the drinking in the dark (DID) procedure to model sugar binging. The DID procedure was originally developed to induce alcoh...
ADAMTS5−/− joints had a significantly thinner subchondral plate and less epiphyseal trabecular bone compared to WT joints. Histology confirmed previous findings that ADAMTS5−/− mice have significantly less cartilage damage than WT in the instability-induced OA model. Although the subchondral ...
By comparing whole genomes of 36 inbred mouse strains downloaded from the Sanger Institute, we identified positive selected genes (PSGs), examined their expression via RNA-seq, and tested the function of some selected loci in this model organism. Results Samples and whole-genome sequencing To ...
For intravitreal implant injection, the mice were anesthetized using ketamine-xylazine [46]. This combination has also been used for developing an ocular hypertension model [47]. However, this combination is shown to induce corneal damage, irrespective of the treatments applied, to prevent corneal de...
Experimentally, MRV-3 infection of infant mice has been used to model human hepatobiliary disease, pancreatitis, diabetes mellitus and lymphoma [8], [291]. The literature on MRV-3 infections in mice is dominated by studies on experimentally infected animals. The virus can cause severe pantropic ...
However, the detailed antiatherosclerosis mechanisms involved have yet to be elucidated. Nippostrongylus brasiliensis (N. brasiliensis), also known as rat hookworm, can infect rodent animals and exhibits a similar life cycle and infe...
The two mouse mutants, obese (ob) and diabetes (db) , cause similar diabetes-obesity syndromes that are characterized by a marked increase in apparent met... DL Coleman - 《Diabetologia》 被引量: 100发表: 1982年 Effect of a high-fat diet on obese-hyperglycaemic and non-obese Bar Harbor...
model in which the transneuronal tracer barley lectin was specifically expressed in GnRH neurons9. These include the medial amygdala and the posteromedial part of the bed nucleus of the stria terminalis, both known to relay pheromone signals, as well as the medial preoptic area, the ventrolateral...
B. Transfer of a functional human immune system to mice with severe combined immunodeficiency. Nature 335, 256–259 (1988). The original description of the use of CB17- scid mice as hosts for human PBMCs, known as the Hu-PBL-SCID model. Article CAS PubMed Google Scholar McCune, J. ...