Viral Structural ProteinsViral Envelope ProteinsA number of studies have signified the importance of neurons in the pathogenesis of the acute as well as chronic forms of MHV-induced neurologic disease in rodents. Following intranasal inoculation, MHV strains A59 and JHM invade the murine CNS by way...
Abstract The genome of the murine Coronavirus MHV-JHM is a positive-stranded RNA of approximately 30 Kb, which encodes 4 structural proteins (N, M, S and HE) and at least 4 non-structural proteins. The location of the major open reading frames (ORFs) in the genome is shown in Fig. 1...
The various strains of mouse hepatitis virus exhibit distinct organ tropisms. MHV-4(JHM) and MHV-3 are predominantly neurotropic and hepatotropic respectively. Studies on the mechanisms involved in organ specific infection of mouse hepatitis virus (MHV) have focused on several factors such as dose,...
SummaryA bacterial expression vector was constructed to encode a fusion protein which had, at its carboxy terminus, a polypeptide encoded within the 5′ proximal open reading frame of the coronavirus MHV-JHM mRNA 4. This polypeptide was isolated and used to produce an antiserum. The antiserum rea...
Summary Five prototype strains of mouse hepatitis virus (MHV) -1,-3, -S,- A59 and -JHM were analyzed for their ability to induce interferon (IFN) in seven cell lines of rodent origin. Induction of IFN by all of the prototype MHV strains was infrequent and unpredictable, while IFN was ...
不管是否为肠外途径接种.在一些组织中出现引人注目的巨细胞,肝脏出现灶性坏死区.幼龄大鼠,棉鼠和仓鼠大脑内接种时也易感.此后,另一些学者在各种情况下分离出许多和JHM不同,彼此之间主要在致病性上不同的致病因子.甚至现在,新的和那些已描述过的毒株在毒力,组织亲合性,宿主范围,免疫力方面相似或不同的毒株还可出...
This is consistent with previous reports suggesting that the spinal cord is the major site of viral persistence during chronic infection with JHM and MHV-A59. Mice infected with non- demyelinating viruses MHV-2 and Penn97-1, and uninfected controls, were negative. 4. CONCLUSIONS Using targeted...
Mouse hepatitis virus (JHM strain) type 4 induces acute encephalitis followed by death in many strains of laboratory mice. Immunohistochemical study in vivo and analysis of mouse neuronal cells in vitro both indicate that the target cell... Knobler,L R. - 《Journal of Experimental Medicine》 被...
REl'INOPATHY FOLI.(M!NG INTRAVITREAL INJECI'ION OF MICE WITH MHV STRAIN JHM Susan G. Robbins, Barbara Detrick and John J. Hooks National Eye Institute, National Institutes of Health Bethesda, Maryland INTROOucrION The causes of many human degenerative and inflammatory diseases of the retina ...
摘要: 用等量混合的四株病毒液(MHV_1,MHV_3,A_(59) ,JHM)定量由腹腔注射,人工感染SCID小鼠,BALB/c裸鼠,BALB/c小鼠后,取脑,肺,肝,脾,肾组织,经固定,做常规石蜡切片,苏木素伊红(HE)染色,光镜下观察三个不同品系小鼠的组织病理学变化.结果表现为各品系小鼠肝,脾组织病理...