Single-cell suspensions obtained from enzymatically digested murine lungs were labeled for surface antigens (CD45/CD31/epithelial cell adhesion molecule (EpCAM)/ major histocompatibility complex class II (MHCII)) and for pro-surfactant protein C (proSP-C), followed by FACS analysis for surface ...
To verify prior reports of homeostatic AT2 MHCII expression, we assessed MHCII on both mouse and human AT2s by flow cytometry. We found that naive wild-type C57Bl/6 (B6) AT2s, identified as CD45−CD31−EpCAMint(Supplementary Fig.1)22, uniformly express MHCII (Fig.1a). Similarly, ...
C? 3. 辅佐分子 与TCR有关的分子:CD3,CD4, CD8 其他辅佐分子:CD28,CD40L,CD45, LFA-1,CD2 (二)、T-APC相互作用中的免疫突触 1994年 Paul提出,1999年Grakoui提出新概念 T-APC:复杂而有序的超分子结构,称多分子激活聚集体(supra-molecular activation cluster, SMAC) 1. 免疫突触的形成和结构 脂筏 lipid ...
scm 细胞,与幼稚细胞一样,是cd45ro-、ccr7+、 cd45ra+、cd62l+(l-选择素)、cd27+、cd28+和il-7rα+,但它们还表达大量的cd95、il-2rβ、cxcr3和lfa-1,并显示出记忆细胞独特的许多功能属性);(ii)中央记忆t cm 细胞表达l-选择素和 ccr7,它们分泌il-2,但不分泌ifnγ或il-4,和(iii)效应记忆t em ...
Relative expression of Dkk1, Wnt target genes and Foxn1 in sorted TECs (CD45 MHCII+EpCAM+) as well as TECs in vivo.doi:10.1093/tropej/fmn030neonatalprematurityretinopathy of prematurityWe studied growth hormone (GH) stimulation and insulin-lik...
Culture expanded CD45- MHCIIlo/-EpCAMlo Sca1+ CD49FloCD29+H2BGFP LRCs maintain a surface phenotype similar to mesenchymal stem cells.Masako, OsadaVaran, J. SinghKenmin, WuDerek, B. Sant’AngeloMark, Pezzano
Results 36% of SCLC tumors showed significant stromal or intraepithelial CD45 + immune cell infiltration. These patients exhibited significantly increased overall survival (OS) (vs. patients with immune-deserted tumors). High CD8 expression was associated with increased median OS. We found STING ...
ccr7+、cd45ra+、cd62l+(l-选择素)、cd27+、cd28+和il-7rα+,但它们还表达大量的cd95、il-2rβ、cxcr3和lfa-1,并显示出记忆细胞独特的许多功能属性);(ii)中央记忆tcm细胞表达l-选择素和ccr7,它们分泌il-2,但不分泌ifnγ或il-4,和(iii)效应记忆tem细胞,然而,不表达l-选择素或ccr7但产生效应细胞...
ccr7+、cd45ra+、cd62l+(l-选择素)、cd27+、cd28+和il-7rα+,但它们还表达大量的cd95、il-2rβ、cxcr3和lfa-1,并显示出记忆细胞独特的许多功能属性);(ii)中央记忆tcm细胞表达l-选择素和ccr7,它们分泌il-2,但不分泌ifnγ或il-4,和(iii)效应记忆tem细胞,然而,不表达l-选择素或ccr7但产生效应细胞...
ccr7+、cd45ra+、cd62l+(l-选择素)、cd27+、cd28+和il-7rα+,但它们还表达大量的cd95、il-2rβ、cxcr3和lfa-1,并显示出记忆细胞独特的许多功能属性);(ii)中央记忆tcm细胞表达l-选择素和ccr7,它们分泌il-2,但不分泌ifnγ或il-4,和(iii)效应记忆tem细胞,然而,不表达l-选择素或ccr7但产生效应细胞...