2025年3月,王忠敏主任医师在《Cancer Letters》【IF9.1,Q1】杂志在线发表题名为“Irreversible electroporation combined with PD-L1/IL-6 dual blockade promotes anti-tumor immunity via cDC2/CD4+T cell axis in MHC-I deficient pancr...
Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers 发表杂志:Cancer cell 影响因子:50.3 发表时间:2024.4.8 背景: I类主要组织相容性复合体(MHC)缺陷所致的抗原提呈...
In this study, qRT-PCR, western blot, and flow cytometry were used to detect the mRNAs and proteins of NLRC5, β2m, and HLA-ABC in MHC class I–deficient human SKBR3 breast cancer cells after IFN-γ treatment. It was shown that the relative levels of NLRC5 mRNA, β2m mRNA, and ...
In MHC class I–deficient hosts, natural killer (NK) cells are hyporesponsive to cross-linking of activation receptors. Functional competence requires engagement of a self–major histocompatability complex (MHC) class I–specific inhibitory receptor, a process referred to as "licensing." We previous...
The role of major histocompatibility complex (MHC) class I expression in natural killer (NK) cell target recognition is controversial. Normal T cell blasts from MHC class I--deficient mutant mice were found to serve as target cells for NK cells in vitro, which suggests that MHC class I molec...
Major histocompatibility complex class I deficiency (HLA Class I Deficiency), also referred to as bare lymphocyte syndrome type I, is an extremely rare autosomal recessive primary immunodeficiency arising from defects in the transporter associated with antigen processing (TAP) 1,TAP2, orTAPBPgenes (Ha...
Single-cell RNA-sequencing analysis reveals a distinct immune landscape between YTHDF1-deficient and WT tumors To reveal immune microenvironment heterogeneity at single-cell resolution, we performed single-cell transcriptome analysis of tumor-infiltrating CD45+ immune cells from Ythdf1-KO (n = 3...
All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models. These MHC class II molecule-deficient mice were on the NMG genetic background and ...
The modeled peptide-deficient HLA-A*02:01/TAPBPR complex was used as a starting point to determine whether the “scoop loop” conformation was stable in all-atom molecular dynamics (MD) simulations, performed in explicit solvent. To evaluate the stability of our MD simulations, we examined C...
MHC class I-deficient mice. This chapter focuses on class I-deficient mice, including studies of T cell recognition, natural killer (NK) cell responses, lymphocyte development, transplantation, protective immune responses, and immunopathological reactions. Major hi... DH Raulet - 《Advances in ...