Genes within the MHC involved in antigen presentation constitute the most polymorphic loci known in vertebrates [52,53]. The variability of the MHC-molecules is correlated with the diversity of the T-lymphocyte receptors which in turn determine the disease and parasite resistance of an organism and...
However, their presence does raise the question whether the third criterion for tolerance, i.e. absence of histologic evidence of rejection, has been fully achieved with this CD117-ADC conditioning, transient immunosuppression and bone marrow transplantation protocol and provides an opportunity to fully...
Importantly, these findings question the widely accepted notion that microglia are the only MHC class-II expressing cells in the central nervous system. To our knowl- edge this is the first time the existence of a population of MHC-II/SOX2-positve cells in the germinal zone of the human ...
Importantly, these findings question the widely accepted notion that microglia are the only MHC class-II expressing cells in the central nervous system. To our knowl- edge this is the first time the existence of a population of MHC-II/SOX2-positve cells in the germinal zone of the human ...
The question mark (?) above HLA-F reflects the unknown block location of HLA-F. The map is shown to approximate scale to highlight the size of the largely uncharacterized regions between the HLA genes. (For interpretation of the references to colour in this figure legend, the reader is ...
by the rs4774C allele seems to be not related to a different expression pattern of the MHC2TA gene, but in this study we did not analyze the MHC2TA protein levels or the effectiveness of this protein as class II transactivator. Further studies should be performed to clarify this question...