Rowland-Jones SL, Dong T, Fowke KR, Kimani J, Krausa P, Newell H, Blanchard T, Ariyshi K, Oyugi J, Ngugi E, Bwayo J, MacDonald KS, McMichael AJ, Plummer FA (1998) Cell responses to multiple conserved HIV epitopes in HIV-resistant prostitutes in Nairobi. J Clin Invest 102:1758...
variability is believed to be maintained by pathogen-driven selection, mediated either through heterozygote advantage or frequency-dependent selection. Up to now, most of our knowledge has derived from studies in humans or from model organisms under experimental, laboratory conditions. Empirical support f...
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Understanding the relative effects of natural selection and demography at functionally important immune genes in wildlife is increasingly important as emerging epizootic and zoonotic diseases threaten animal and human health [67,68]. Our comparative analysis of range-wide variation at the MHC and neutral...
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Blood was drawn from macaques or human subjects into EDTA tubes at the WNPRC or University of Wisconsin Hospital respectively and layered over Ficoll-Paque Plus (GE Healthcare Bioscience, Uppsala, Sweden); peripheral blood mononuclear cells (PBMC) were isolated by density centrifugation. We then sp...
Computational prediction of the peptides presented on MHC class I proteins is an important tool for studying T cell immunity. The data available to develop such predictors has expanded with the use of mass spec to identify naturally-presented MHC ligands. In addition to elucidating binding motifs,...
So far, there is limited evidence for contrasting evolution of both MHC classes in higher vertebrates, where all MHC genes are linked in a cluster on the same chromosome (Klitz et al., 1986; Bonneaud et al., 2004; Kuduk et al., 2012). Here, we investigated the molecular evolution of...
Krmpotic A, Busch DH, Bubic I, Gebhardt F, Hengel H, Hasan M, Scalzo AA, Koszinowski UH, Jonjic S (2002) MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo. Nat Immunol 3:529–535 Article CAS PubMed Google Scholar Iizuka K, Nakajima C, Iizuka...