关键词:主要组织相容性复合体,神经网络,MHCII类亲和肽预测上海大学硕士学位论文VIABSTRACTThemajorhistocompatibilitycomplexII(MHCII)moleculesplayacentralroleinhumanimmunesystem.BypresentingthebindingpeptidetohelperTcells,MHCIImoleculestriggeradaptiveimmuneresponsetoinfections.Therefore,accuratepredictionofMHCIIbindingpeptides...
不同软件HLA的各个亚型的预测所得指标不一致,提示综合运用不同软件对多肽表位进行预测十分必要.关键词:MHC—II;表位预测;临界值;软件;比对中图分类号:R318文献标识码:A文章编号:1672.6278【2010)02.0128—05ComparativeAssessmentofDifferentSoftwaresforMHC——IIAntigenEpitopePredictionLIShengtao,LIUChangwen,ZOUZehong,...
码器处理可变长度肽序列和MHC等位基因,改进MHC‑I和II类肽结合预测。同样, DeepSeqPanII(Liu Z,Jin J,Cui Y et al.DeepSeqPanII:an interpretable recurrent neural network model with attention mechanism for peptide‑HLA class II binding prediction,IEEE/ACM Transactions on Computational Biology and 4 ...
MHCII peptidomics was used to discover complex bacterial epitopes and host antigen processing pathways. Novel insights into the features of antigenicity are leveraged to build an algorithm for prediction of immunodominant epitopes. Use of immunodominant epitopes is described.GRAHAM, DANIEL B....
Reliable and ultra-fast DNA and RNA sequencing have been achieved with the emergence of high-throughput sequencing technology. When combining the results of DNA and RNA sequencing for tumor cells of cancer patients, neoantigens that potentially stimulate
本文以MHC II类亲和肽预测为研究目标，提出基于集成神经网络的新MHC II类亲和肽预测算法MHC2NNZ，该方法包含了两种新的特征提取方法。在标准数据集上的性能测试表明本算法具有良好的性能。本文的创新性工作具体如下：（一）提出一种新多肽两侧区域（PFR）特征提取方法。新PFR特征提取方法采用z描述符物理化学特征提取PFR...
一 .MHC—II类抗原表位预测软件的对比评价* 李胜涛,刘昌文,邹泽红,陶爱林△ (广州医学院第二附属医院,广州510260)摘要:比较不同MHC—II类抗原表位预测软件的优缺点,为后续应用提供依据.在众多mA—II类抗原 表位中,选取ⅢA—DR的6个表位(DRB10101,03O1,0401,0701,1101和1501)为代表,选取MHCBN数据 库中的309条...
7. Rock, K. L., Reits, E. & Neefjes, J. Present yourself! By MHC class I and MHC class II molecules.Trends Immunol.37, 724–737 (2016). 8. Sarkizova, S. et al. A large peptidome dataset improves HLA class I epitope prediction across mo...
Improved MHC II epitope prediction — a step towards personalized medicineNumerous neoepitope-based vaccination strategies are in testing for clinical use in the treatment of cancer. Rapid identification of immunostimulatory neoantigen targets hastens neoantigen vaccine development. Papers recently published in...
factor IX complexa sterile, freeze-dried powder consisting of partially purifiedcoagulation factorIX fraction, as well as concentrated factor II, VII, and X fractions, of venous plasma from healthy human donors. It is used in the prophylaxis and treatment of bleeding in patients withhemophilia B,...