In cells derived from the mutator mouse model, which represents a system of premature aging, disturbed mitochondrial function resulted in a concerted upregulation of the MHC I antigen presentation pathway as demonstrated by proteomic and FACS analysis. Importantly, expression and activity of the ...
During aging, spinal cord motoneurons show characteristic changes including the loss of afferent boutons, a selective process that associates with gliosis and behavioral motor impairment. Evidence suggests that the major histocompatibility complex Class I (MHC I) system may be involved in synaptic plas...
Following seven cycles of passaging, B16/F10 cell lines exhibiting resistance to ICI treatment (ICIs-resistant B16/F10) were derived, and were unresponsive to combination treatment in vivo (Fig. 1J). Western blot analysis showed that YTHDF1 was significantly upregulated in resistant B16/F10 ...
· Dorothy Ayers Counts and David R. Counts. 1985. “I’m Not Dead Yet! Aging and Death: Process and Experience in Kaliai.” [fromAging and Its Transformations: Moving TowardDeathin Pacific Societies.(Association for Social Anthropology in Oceania Monograph)] o Short excerpt about this small ...
(MHC), or B complex, consists of several clusters of highly polymorphic genes. Like their mammalian counterparts, the avian MHC exerts genetic influence over a variety of important biological functions such as immune response, disease resistance, growth and development, aging, and reproduction. ...
Antigen presentation via major histocompatibility complex class I (MHC I) molecules is essential to mount an adaptive immune response against pathogens and cancerous cells. To this end, the transporter associated with antigen processing (TAP) delivers sn
恒定链(invariant chain,Ii)能结合主要组织相容性复合体(major histocompatibility complex,MHC)Ⅰ类和Ⅱ类分子,并在MHC递呈抗原中起重要辅助作用.为了探讨鱼类Ii和MHC分子体外结合关系,本研究采用Pull-down方法检测草鱼(Ctenopharyngodon idellus) Ii与MHC Ⅰ类或Ⅱ类分子的结合.克隆草鱼Ii (711 bp)、Mh...
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Aberrant regulation of autophagy has been implicated in the pathogenesis of diverse disease states, such as neurodegenerative disorders [7], microbial infection [8], endocrine diseases [9], myopathies [10], cardiovascular diseases [11], aging [12], and cancer [13]. Except for its basal ...
Genes encoding MHC class I-like, class II-like and molecules have evolved to assume specific immunological functions. Some class I-like molecules, including H-2M3 and , present formylated bacterial or have distinct motifs. The class II-like and gene products play a role in presentation of ant...