On the other hand, MHC haplotype did not influenced resistance/susceptibility; since mice lineages displaying a same genetic background but different MHC haplotypes (H2b or H2d) developed similar mortality and cyst numbers after infection with those strains. In contrast, the C57BL/6 genetic back...
We have tested a MLR response by spleen cells of the strains O20, B10.O20, and 16 OcB/Dem strains through stimulation by cells from strains C57BL/10 (H2b), BALB/c (H2d), CBA (H2k), and DBA/1 (H2q) alloantigens. Proliferative response of O20, B10.O20 and OcB/Dem strains ...
Similarly, responding cells from CD4+CD25+ T-cell BM transplant recipients failed to generate CTLs against targets bearing donor (H2b) or host (H2d) MHC, whereas BM-only recipients who rejected the donor marrow did generate anti-H2b CTLs (Figure 5C). Download: Download high-res image (18...
When Ovalbumin was fed instead of Kb encoding nanoparticles (Kb-NP) or Balb/c (H2d) grafts were used instead of C57BL/6 (H2b) grafts as antigen controls, both groups showed no reduction of intimal thickness indicating an antigen-specific mechanism. In addition, analysis of peripheral blood ...
In mixed chimeras where 564Igi H2b/b, H2b/d and H2d/d cells competed head-to-head in the same environment, we observed a significantly higher inclusion of H2b/b cells in GC and PC compartments relative to their representation in the B cell repertoire, compared to ...
To test the in vivo relevance of these findings, 2×106B10 (H2b) mouse bone marrow-derived DC progenitors (NLDC 145+, MHC class II+, B7-1dim, B7-2-/dim) that induced T-cell hyporesponsiveness in vitro were injected systemically into normal C3H (H2k) recipients. Seven days ...
We have previously shown that H2b with or BALB genetic backgrounds have higher basal levels of IgG2a than H2k and H2d congenic strains and, hence, have low IgG1/IgG2a ratios, which is consistent with a T1 cytokine milieu. The phenotypic marker of the high IgG2a levels, denoted immunoglobulin...
lymphocytes from blood, our results suggest that chromosomal segments known to encode minor H antigens detected in the context of the H2bhaplotype are antigenically complex in that they also frequently encode minor H antigens that can be detected in the context of at least the H2dand H2k...
To determine the role of major and minor histocompatibility antigens, syngeneic, B6Ly5.2 (H2b, CD45.1+)C57BL/6 (H2b, CD45.2+), MHC-matched B6Ly5.2 (H2b, CD45.1+)C3H.SW (H2b, CD45.2+) and MHC-mismatched C57BL/6 (H2b)BALB/c (H2d) chimeras were constructed after lethal TBI (900...