Figure 2.HLA-DR-specific memory B cell clones isolated from peripheral blood using ProT2® MHC Class II Tetramers. A, Representative example of 3 independent experiments depicting the flow cytometry gating strategy to live single cell sort CD3-CD27+IgD-HLA-DR tetramer double positive B cells ...
抗原特异性CD4+ T细胞的直接检测一直很困难,因为这些T细胞的数量少(低至100,000个白细胞中的1个)和亲和力低,ProT2® MHC Class II Tetramers四聚体允许研究者通过流式细胞术准确检测单个抗原特异性CD4+T细胞。它们也可以用来分离细胞,用于培养、扩增和进一步研究。ProT2® MHC Class II Tetramers研究者能够深入...
Proimmune ProT2® MHC Class II Tetramers用于新冠肺炎感染和接种疫苗队列中功能性CD4+ T细胞的免疫监测 CD4+ T细胞在对病毒感染的免疫反应中起着至关重要的作用。新型冠状病毒感染和疫苗接种引起对病毒刺突蛋白的强CD4+ T细胞反应,包括与中和抗体发展相关的循环T卵泡辅助细胞。研究者使用了一种新的HLA-DRB1*15:0...
The article focuses on MHC Class II Tetramers and its application in disease and vaccine studies. It is stated that they are important for the characterization of the phenotype of CD4 T cell immune responses. It states that various issues should be considered for the experimental choice including...
MHC Class II Tetramers Quantitatively Detect DP4-Restricted, Antigen Specific CD4+ T LymphocytesmelanomaimmunotherapyuveitisautoimmunityCTLA-4 antibody... M Ye,K Kuus-Reichel,Z Zhu,... - 《Journla of Immunotherapy》 被引量: 0发表: 2004年 De novo generation of antigen-specific CD4+CD25+ regulator...
细胞毒性T细胞(cytotoxic T cell,CTL),也称杀伤性T细胞,能特异性杀伤带抗原的靶细胞,如移植细胞、肿瘤细胞及受微生物感染的细胞等。 活化的细胞毒性T细胞分泌功能性细胞因子,如IL-2、干扰素γ(IFNγ)、肿瘤坏死因子α(TNFα)等, 因此传统检测方法通过...
Targeting CD4+ T cells through their unique antigen-specific, MHC class II-restricted T cell receptor makes MHC class II tetramers an attractive strategy to identify, validate and manipulate these cells at the single cell level. Currently, generating class II tetramers is a specialized undertaking...
Soluble tetramers of major histocompatibility complex (MHC) class I or class II molecules are a biotechnological reagent produced in the laboratory to analyze the specificity of antigen receptors expressed by T cells. In nature T cell receptors (TCR) recognize peptide antigens bound to membrane MHC...
ProT2™ MHC Class II 四聚体可以与研究者实验室已建立的其他Class II 四聚体试剂一起使用。 ProT2™ MHC Class II 四聚体染色流感肽段的刺激CD4+T细胞表位ProT2™染色---实验数据来源于ProImmune 图2. 肽段PKYVKQNTLKLAT (Influenza A HA 307319)刺激正常志愿者的PBMCs,培养13天后,DRB1*01...
英文名称:ProT2® MHC Class II Tetramer (APC Labeled) 别名:ProT2® MHC Class II Tetramer (APC Labeled) 产地:英国 品牌:ProImmune 包装规格:50/150/500test 货号:ProT2® MHC -APC 是否进口:是 ProT2®MHC II类四聚体(APC标记) 现货!!!