Figure 2.HLA-DR-specific memory B cell clones isolated from peripheral blood using ProT2® MHC Class II Tetramers. A, Representative example of 3 independent experiments depicting the flow cytometry gating strategy to live single cell sort CD3-CD27+IgD-HLA-DR tetramer double positive B cells ...
APCs use MHC class II molecules to provide CD4-positive T cells with an overview of the surrounding tissue environment. These interactions are important for activating T cells during infection. Latest Research and Reviews A naturally selected αβ T cell receptor binds HLA-DQ2 molecules without co...
通过基因和药物抑制巨噬细胞中的 PAD4 可以阻止肿瘤小鼠模型的肿瘤进展,同时巨噬细胞主要组织相容性复合体(MHC)II 类表达和 T 细胞效应功能也会增加。从机理上讲,PAD4 在精氨酸 121 处瓜氨酸化 STAT1,从而促进 STAT1 与活化 STAT1 蛋白抑制剂(PIAS1)之间的相互作用,而 PAD4 的缺失会取消这种相互作用,从而消除...
近日，来自瑞士University of Lausanne的Alexandre Harari和David Gfeller研究组在Immunity上发表题为Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes的文章，就上述问题进行了深入探讨。人类的MHC-II也被称之为HLA-II，包含有三个可以直接给CD4+T细胞递呈抗原的...
MHC-抗原肽复合物(即pMHC)向T细胞呈递抗原肽(表位),可特异性结合T细胞表面受体(TCR)。TCR在T细胞表面通常以多个相同拷贝(>1×105)表达。其中,CD8+T细胞主要识别由I类MHC分子呈递的抗原肽,而CD4+T细胞则主要识别由II类MHC分子呈递的抗原肽。其中:人类MHC→H...
在上述背景下,MHC-II缺陷型的肿瘤细胞是否能被CD4+ T细胞所识别、杀伤呢? 2023年7月3日发表于Nature Immunology的《Neoantigen-specific stem cell memory-like CD4+ T cells mediate CD8+ T cell-dependent immunotherapy of MHC class...
The present disclosure provides T-cell modulatory multimeric polypeptides (TMMPs) comprising a type 1 diabetes (T1D)-associated peptide epitope, MHC class II polypeptides, and one or more immunomodulatory polypeptides. A TMMP of the present disclosure is useful for modulating activity of a T cell....
MHC class II molecules expressed on professional antigen-presenting cells like DCs. These cells probably internalize apoptotic bodies or necroticdebris from tumor cells and present fragments to the CD4+T cells, which then stimulate cytotoxic Tcell proliferation(Ossendorpet al., 1998). State-of-the-...
Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues l...
dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-...