Here we report twelve cryo-electron microscopy (cryo-EM) structures of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers in different conformational states, including inactive, intermediate inactive, intermediate active and fully active conformations. These structures provide a full picture of conformational...
Atomic coordinates and cryo-EM density maps for the structures of mGlu2–Gi1 and mGlu4–Gi3 complexes have been deposited in the PDB under identification codes 7E9G and 7E9H, respectively, and in the Electron Microscopy Data Bank under accession codes EMD-31031 and EMD-31032, respectively. Th...