The first study showing that orthosteric agonist of group III mGluRs can cross the BBB after intraperitoneal (ip) administration in rats was conducted by Palucha-Poniewiera and colleagues using (1 S,3R,4 S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], ACPT-I [127]. ACPT-I is one of...