Lin and colleagues observed similar findings in the in vitro and ex vivo studies that analyzed the activity of the mGlu7/8 heterodimer relative to the corresponding homodimers [90]. They found that two highly structurally related mGlu7R NAMs, VU6010608 and VU6010953, exhibited distinct activity...
Cell counts for a region are based on cell counts from a single brain section from each mouse from each treatment group. There was no significant variation of total number of 5-HT-positive cells within each treatment group. Colocalization of c-Fos immunoreactivity with 5-HT in the cell ...
The title compound (27 mg, 0.10 mmol) was prepared from 4-chloro-6-(1H-pyrazol-1-yl)pyrimidine (Intermediate 34, 225 mg, 1.25 mmol) and (3-cyano-5-methylphenyl)boronic acid (Intermediate 26, 200 mg, 1.24 mmol) at 90° C. using the methods of Example 2, 3-chloro-5-[6-(pyridin...
Two mice in each group were randomly selected and analysed in this study. The investigator was blinded to the group allocation during the experiment. Paraffin-embedded tumours were sectioned into 4 μm sections by Leica RM2255 microtome (Leica, Wetzlar, German). The sections were rehydrated in ...