MGF-505-7RRNF125Hes5JAK1JAK2African swine fever virus (ASFV) is a large DNA virus that is highly contagious and pathogenic in domestic pigs with a mortality rate up to 100%. However, how ASFV suppresses JAK-STAT1 signaling to evade the immune response remains unclear. In this study, we ...
近日,华南农业大学兽医学院张桂红教授课题组以华南农业大学兽医学院为第一单位,在Journal of Virology在发表了题为“African Swine Fever Virus MGF505-7R Interacts with Interferon Regulatory Factor 9 to Evade the Type I Interferon Signal...
敲除MGF505-7R基因的重组病毒能够诱导更高水平的IL-1β和IFN-β的产生,表明pMGF505-7R对IL-1β和I型干扰素产生具有抑制作用。进一步研究发现,pMGF505-7R通过与IKK复合物相互作用抑制IL-β基因的转录,并且其靶向NLRP3炎症复合体抑制IL-β的分泌;而在I型IFN信号通路中,pMGF505-7R靶向IRF3抑制I型IFN的产生。动物...
We further found that MGF-505-7R promoted the expression of the autophagy-related protein ULK1 to degrade STING, whereas ULK1 was elevated in MGF-505-7R-deficient ASFV-infected cells. Moreover, MGF-505-7R-deficient ASFV induced more IFN-β production than wild-type ASFV and was attenuated in...
哈兽研发现非瘟病毒致病力与MGF505-7R 基因相关,为疫苗研发提供新理论依据 近日,中国农业科学院哈尔滨兽医研究所在非洲猪瘟病毒致病机制研究上取得新进展,相关研究结果以“pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1βand type I IFN production”为题,于7月26...
近日,中国农业科学院哈尔滨兽医研究所在非洲猪瘟病毒致病机制研究上取得新进展,相关研究结果以 “pMGF505-7R determines pathogenicity of African swine fever virus infection by inhibiting IL-1βand type I IFN production”为题,于7月26日在线发表在《公共科学图书馆-病原学(PLoS Pathogens)》上。该研究发现非...
MGF505-7Rimmune evasionAfrican swine fever (ASF) is an acute and severe infectious disease caused by the ASF virus (ASFV). The mortality rate of ASF in pigs can reach 100%, causing huge economic losses to the pig industry. Here, we found that ASFV protein MGF505-7R inhibited the beta ...
We developed a novel recombinant ASFV strain by deleting MGF360-10L and MGF505-7R, significantly reducing virulence in pigs. In the inoculation experiment, pigs were infected with 104 50% hemadsorption doses (HAD50) of the mutant strain. All the animals survived the observation period without ...