MGC018 is an investigational anti–B7-H3 IgG1 antibody-drug conjugate with a duocarmycin-based DNA-alkylating payload that can damage DNA in both dividing and nondividing cells, causing cell death.1 As previously presented, Phase 1 testing of single-agent MGC018 (NCT03729596) demonstrated an ...
Apoptotic cell death was investigated by the Annexin V staining. Pseudometastatic, orthotopic, and resected mouse NB models were developed via tumor cells tail vein injection, implantation in the adrenal gland, or implantation followed by surgical resection of the primary tumor mass, respectively, to...