The reactions of (dpp-BIAN)Mg(THF)(3) (1) {dpp-BIAN = 1,2bis[(2,6-diisopropylphenyl)imino]acenaphthene} with ethyl halides EtX (X = Cl, Br, I) in hexane proceed by single-electron transfer (SET) from the metal complex to the organic halide. Complexes [(dpp-BIAN)(Et)]MgX(THF...
After the Grignard reagent forms on the reactive metal surface, it dissolves away from the site and sets the site free, exposing it to the organic halide. After the initiation stage of the reaction, mass transfer of the organic halide to the reactive site is considered to be the ...
2-chloro-N-methoxy-N-methylacetamide (5.16 g, 37.5 mmol) in THF (200 mL) at -78℃ dropwise. The reaction was allowed to warm slowly to room temperature overnight andquenched with 1N hydrochloric acid. The layers were separated and the organic phase dried(Na...
- 《Journal of Organic Chemistry》 被引量: 1847发表: 1996年 TiCl((OPr)-Pr-i)(3) and NaBH(OAc)(3): an efficient reagent combination for the reductive amination of aldehydes by electron-deficient amines. Forsee ChemInformin Full Text. Corey D. Gutierrez,Vassilios Bavetsias,Edward McDonald -...
Isotopically-labeled compounds of the invention can generally be prepared by conventional techniques known to those skilled in the art or by processes analogous to those described herein, using an appropriate isotopically-labeled reagent in place of the non-labeled reagent otherwise employed. The term ...
2-chloro-N-methoxy-N-methylacetamide (5.16 g, 37.5 mmol) in THF (200 mL) at -78℃ dropwise. The reaction was allowed to warm slowly to room temperature overnight andquenched with 1N hydrochloric acid. The layers were separated and the organic phase dried(Na...