adjuvantantigenic variationemulsioninfluenzainfluenzahumaninfluenza vaccineprevention & controlsqualenevaccinesCorrelated with increasing chronologic age, immunosenescence impairs the response to influenza vaccines. MF59-adjuvanted influenza vaccine (Fluad, Novartis, Basel, Switzerland) elicits a stronger and broader ...
in Molecular Medicine., Vol 42: Vaccine Adjuvants: Preparation Methods and Research Protocols
Mechanism and application progress of MF59 adjuvant in influenza vaccine 引用 收藏 分享 摘要 流感疫苗接种是预防流感病毒传播最有效的途径,在流感疫苗中添加佐剂不仅能增强机体免疫应答反应,还可节省抗原剂量。除经典铝佐剂外,MF59佐剂作为第2个上市且已广泛应用于人体疫苗的佐剂,其诱导抗体的能力不仅与铝佐剂相当,...
The effect of the proprietary adjuvant MF59 on the immunogenicity of a recombinant hepatitis B virus (HBV) vaccine, PreS2+SAg, was investigated in baboons. The magnitude and duration of the antibody response to hepatitis B surface antigen (anti-HBs) induced by the HBV/MF59 vaccine was compared...
The cell-derived pandemic H1N1 influenza vaccine was also adjuvanted with the emulsion adjuvant MF59, and support for its similar safe use was sought. We sought to evaluate in vitro allergenicity of the MF59-adjuvanted cell-derived pandemic H1N1 influenza vaccine in subjects with dog allergy, with...
(Fluad™) is now licensed in more than 20 countries worldwide and more than 85 million doses have been administered. More recently the vaccine adjuvant has also been shown to be safe and effective in young children and resulted in a significant increase in influenza vaccine efficacy in a ...
The adjuvanted influenza vaccines with novel adjuvants: experience with the MF59-adjuvanted vaccine. Vaccine. 2001; 19 :2673–2680. doi: ... A Podda - 《Vaccine》 被引量: 621发表: 2001年 The comparative effectiveness of adjuvanted and unadjuvanted trivalent inactivated influenza vaccine (TIV) ...
This article outlines the composition, mode of action and clinical efficacy of new generation influenza vaccine adjuvants. Thoughts and proposals on further development of adjuvants are also addressed. KEYWORDS: Influenza vaccines;Adjuvants, immunologic;Composition;Action mechanisms;Applications Corresponding ...
MF59 adjuvant has a significant impact on the immunogenicity of flu vaccines in the elderly, and also in adults who are chronically ill, an additional population who may need an improved influenza vaccine. MF59 has also been shown to have a significant impact on the immunogenicity of pandemic ...
The history of MF59 (R) adjuvant: a phoenix that arose from the ashesvaccinesenvironmentsafety(Novartis)influenzaThe first clinical trial of an MF59(庐)-adjuvanted influenza vaccine (Novartis) was conducted 20聽years ago in 1992. The product that emerged (Fluad(庐), Novartis) was licensed first...