Using a combination of all-atom and coarse-grained MD simulations and sequence covariation analysis, we characterized the interface between MexA and OprM in the context of the entire efflux pump. These analyses suggest a plausible mechanism by which OprM is activated via opening of its periplasmic ...
[5] DAMIER-PIOLLE L,MAGNET S,BRÉMONT S,et al.AdeIJK,a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii[J].Antimicrob Agents 临床输血与检验 2023年12月第25卷第6期 Chemother,2008,52(2):557-562. [6] EL-SHAER S , SHAABAN M , BARWA R ,...
RESULTS: Multiplex PCR of mexAB-OprM efflux pump genes revealed that 53 (100%) were positive to all three genes of operon, mexA, mexB and the regulatory gene, mexR. CONCLUSION: P. aeruginosa can cause septicemia in cancer patients and other compromised patients, like patients suffering from ...
inhibition of efflux pump inhibitors (EPIs) MC-207,110 in the 26 strains of multidurg 安徽医科大学硕士学位论文 5 resistant pseudomonas aeruginosa . mexR was amplified with PCR and PCR products were analyzed with DNA Result The drug-resistant rates of 26 strains of multidrug resistant pseudomonas...
Therefore, this study was aimed to determine the interplay between MexAB-OprM and MexEF-OprN in 90 out of 190clinical isolates with an efflux pump overexpression phenotype. Regarding, 33% (30/90) of isolates displayed relevant modifications (RM) defined as frameshift or premature stop, both ...
MexAB-OprM efflux pump in isolates withincrease efflux pump activity. mexR gene of the isolates with overexpressed MexAB-OprMefflux pump was amplified, sequenced and analysed.ResultsOut of 76 MDR isolates, 24 were found to exhibit efflux pump activity phenotypically againstciprofloxacin and meropenem....
How did the inhibition rates of Efflux Pump Inhibitors (EPIs) vary between the MexAB-OprM-producing strain and the MexXY-OprM-producing strain? What potential do the constructed strains expressing P. aeruginosa efflux pumps have for identifying new Efflux Pump Inhibitors (EPIs)? What is berberine ...
1.A multidrug efflux pump inhibitor reduces fluoroquinolone resistance in Pseudomonas aeruginosa isolates.[J].Durupinar B;Yilmaz Coban A;Ekinci B,Chemotherapy: International Journal of Experimental & Clinical Chemotherapy.2004,第1期 2.Antisense RNA regulation of the par post-segregational k...
Expression of MexAB-OprM efflux pump system and susceptibility to antibiotics of different Pseudomonas aeruginosa clones isolated from patients hospitalized in two intensive care units at University Hospital in Bialystok (northeastern Poland) between January 2002 and December 2009. APMIS. 2014;122(10):...
MexAB-OprM specific efflux pumpinhibitors in Pseudomonas aeruginosa. Part 6:Exploration of aromatic substituents. Yoshida K,Nakayama K,Yokomizo Y, et al. Bioorganic and Medicinal Chemistry . 2006Yoshida K,Nakayama K,Yokomizo Y et al.MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa...