It is also used off-label in the treatment of Crohn's disease, as a prophylactic agent after surgery5, and in the treatment of Helicobacter pylori infection.7 It has also been studied in the prevention of preterm births and to treat periodontal disease.1,12 Reduce drug development failure ra...
of an electron to the nitro group of the metronidazole, and formation of a short-lived nitroso free radical. Because of this alteration of the metronidazole molecule, a concentration gradient is created and maintained which promotes the drug’s intracellular transport. The reduced form of ...
When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treat...
When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treat...
Fixeddrug eruption due to metronidazole: review of literature and a case report. International Journal of Pharma Sciences and Research (IJPSR); March 2012; 3(3): 331-334.Wahlang JB, Sangma KA, Marak MD, Brahma DK, Lynrah KG, Ksih A. Fixed drug eruption due to ...
The precise mechanism of action of metronidazole is unclear. Resistance A potential for development of resistance exists against metronidazole. Resistance may be due to multiple mechanisms that include decreased uptake of the drug, altered reduction efficiency, overexpression of the efflux pumps, ...
Metronidazole is an antibiotic, amebicide, and antiprotozoal.[1] It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection [2]. Metronidazole, taken up by diffusion, is selectively absorbed by anaerobic bacteria and sensitive protozoa. Once taken up by ...
Product TypeHUMAN PRESCRIPTION DRUGItem Code (Source)NDC:66993-961 Route of AdministrationTOPICAL Active Ingredient/Active Moiety Ingredient NameBasis of StrengthStrength METRONIDAZOLE(UNII: 140QMO216E) (METRONIDAZOLE - UNII:140QMO216E)METRONIDAZOLE7.5 mg in 1 g ...
Each type of drug was given as a single preoperative intravenous infusion. With metronidazole alone, postoperative infection occurred in 12.9% of all patients. This figure was significantly reduced to 3.2% by adding ampicillin or doxycycline to the prophylactic regimen ( p=0.01 ). The additional ...
(1966). Comprehensive description: L. L. Wearley, G. D. Anthony,Anal. Profiles Drug Subs.5,327-344 (1976). Review of activity, pharmacokinetics and use in anaerobic infection: R. N. Brogdenet al.,Drugs16,387-417 (1978); in rosacea: L. K. Schmadel, G. K. McEvoy,Clin. Pharm.9...