The mode of action of metronidazole in Helicobacter pylori: futile cycling or reduction? J. Antimicrob. Chemother. 41:67-75.Jorgensen, M.A., Manos, J., Mendz, G.L. and Hazell, S.L. (1998). The mode of action of metronidazole in Helicobacter pylori: fu- tile cycling or reduction?
Chart 1.Metronidazole reduction and mode of action. The interaction of reducedmetronidazolespecies with DNA of microorganisms causes inhibition of DNA and RNA synthesis. The DNA double helix is destroyed and the strand is broken. Both theantiprotozoal activityandmutagenicityof metronidazole has been attr...
2. Muller M (1983). Mode of action of metronidazole on anaerobic bacteria and protozoa. Surgery, 93, 165–171. 3. Lau AH, Lam NP, Piscitelli SS (1992). Clinical pharmacokinetics of metronidazole and other nitroimidazole anti-infectives. Clin Pharmacokinet, 23, 328–364. ...
vaginalis.12,13 The mode of action of metronidazole is not entirely clear, but is thought to involve reduction by bacterial 'nitroreductases' to an unstable intermediate which interacts with DNA, effectively pre- venting further replication.14 A number of factors affect the sen- sitivity of ...
Metronidazole which has been widely used in the treatment of trichomoniasis urogenitalis is the most active agent available against obligate anaerobes.--In this review the present data about antimicrobial activity, mode of action, pharmacokinetic behaviour, dosage, clinical use in gynecology and obstetric...
Usage Mode:Injection Contact Supplier Chat Still deciding? Get samples ofUS$ 0.1/Piece Request Sample Shijiazhuang No. 4 Pharmaceutical Co., Ltd. Manufacturer/Factory Gold MemberSince 2018 Audited Supplier Management System Certification ISO 9001, ISO 14001, GMP ...
- 《Bulletin of Haffkine Institute》 被引量: 1发表: 1974年 The possible mode of action of some chemotherapeutic agents in guinea worm disease Oral doses of niridazole at 65.5 mg. per kg. body-weight for 34 days, thiabendazole at 200 mg. per kg. for 4 days and metronidazole at 50 ...
Separation was carried out using an Acclaim 120 C18 column (100 × 2.1 mm, 3.0 μm, Thermo Scientific, USA) in a gradient elution mode. The column and the autosampler were maintained at 40 and 15 °C respectively during operation. The analytes were separated using the mobile ...
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Usage Mode: Injection Contact Supplier Chat Still deciding? Get samples of US$ 0.1/Piece Request Sample Shijiazhuang No. 4 Pharmaceutical Co., Ltd. Manufacturer/Factory Gold Member Since 2018 Audited Supplier Management System Certification ISO 9001, ISO 14001, GMP Add...