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Twelve healthy subjects underwent symptom‐limited cardiopulmonary exercise testing repeated weekly and 2 hours after randomized, double‐blind administration of 50 mg metoprolol tartrate vs 25 mg carvedilol. Baseline heart rate, heart rate at 40% and 70% peak O2 consumption, and maximal exercise...
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After administration of metoprolol, plasma concentrations of the drug are markedly higher in CYP2D6 poor metabolizers (PMs) than in non‐PMs. In a prospective double‐blind 3‐month study, we investigated whether this translates into differences in metoprolol's effects after initiation of therapy. ...
No discriminating factors between flecainide-responders and non-responders were found; the mean plasma level was not significantly different (0.34 mg/L versus 0.52 mg/L, P=0.277). In children with frequent PVCs flecainide led to a significant greater reduction of PVC-burden, compared to metoprolol...